Core 2: Biocomputational and Biostatistics Core

项目摘要/摘要--核心2生物计算和生物统计学 核心2生物计算和生物统计的目的是提供计算和统计支持 这个P01中的四个项目，并与核心合作，以提供解决这种计算和 生物统计学的需要，以适应项目的需要。这确保了设计， 进行和分析所有实验--临床、相关、动物或基础科学--使用可靠的统计方法 适当实现的技术，以及用于分析和解释的专门资源 单细胞RNA测序结果优先提供给项目，用于临床试验的细胞 患者，从这些患者发展出来的细胞系，以及从小鼠实验中获得的。这一中心资源 从而有助于阐明免疫导致的T细胞激活和减弱的变化 对GBM的干预。

PROJECT SUMMARY/ABSTRACT—Core 2 Biocomputation and Biostatistics The purpose of Core 2 Biocomputation and Biostatistics is to provide computational and statistical support to the four Projects in this P01, and to collaborate with Cores to provide to address such computational and biostatistical needs as required to accommodate the needs of the projects. This assures that the design, conduct, and analyses of all experiments—clinical, correlative, animal, or basic science--use robust statistical techniques that are appropriately implemented, and that the specialized resources to analyze and interpret single cell RNA sequencing results are available to the projects on a priority basis, for cells from clinical trial patients, from cell lines developed from those patients, and from murine experiments.. This central resource thereby helps to elucidate the changes in T cell activation and attenuation that result from immunologic interventions in GBM.