Biodefense Training in Host-Pathogen Interactions

描述(由申请人提供)：这项名为宿主-病原体相互作用的生物防御培训的新提案旨在为研究生提供一个种子项目，用于对研究生进行严格的科学教育，研究病原微生物，它们确定人类或动物感染的机制，以及发现预防人类疾病的新疗法或对策。该提案利用了芝加哥大学教师在微生物学和免疫学委员会中的科学优势，以及最近成立的大湖区生物防御和新出现传染病卓越中心提供的基础设施，核心结构中的资源允许通过最先进的显微镜、质谱学、免疫学、动物感染和基因组学设施来研究病原体。芝加哥大学的基础设施承诺允许在BSL-2和BSL-3实验室开展宿主-病原体相互作用方面的工作，这些实验室是专门为疾控中心A-C类精选试剂设计的，以及位于阿贡国家实验室的里基茨区域生物遏制实验室，这是一个由芝加哥大学为国家过敏和传染病研究所建造和运营的联邦实验室。芝加哥大学教职员工致力于在生物防御和寄主病原体研究方面的卓越研究和培训，这反映在最近微生物学系的设立上。随着未来五年任命的七名新教员的大规模增长，微生物学研究生培训的最近扩大，以及教职员工和研究生在该领域已经取得的卓越成就。16名培训教师研究细菌致病、动物病毒、病毒生理学和致病机制、植物致病、耐药微生物、微生物毒素和对感染的免疫反应。学员是从150名申请者中挑选出来的，他们拥有学士学位，平均GRE和GPA分别为1375+5(81%)和3.3。我们培训计划的最终目标是雄心勃勃，旨在建立一个在生物防御和宿主-病原体相互作用方面的主要研究计划。

DESCRIPTION (provided by applicant): This new proposal, Biodefense Training in Host-Pathogen Interactions, is intended as a seed project for rigorous scientific education of graduate students in the study of pathogenic microbes, their mechanisms of establishing human or animal infections, as well as the discovery of novel therapies or countermeasures that prevent human disease. The proposal draws on scientific strengths of University of Chicago faculty in the Committees on Microbiology and Immunology as well as on infrastructure provided through the recently established Great Lakes Regional Center of Excellence in Biodefense & Emerging Infectious Diseases, with resources in core structures that permit the study of pathogens via state of the art microscopy, mass spectrometry, immunology, animal infection and genomics facilities. Infrastructural commitments at the University of Chicago permit work on host-pathogen interactions in BSL-2 and BSL-3 laboratories, specifically designed for CDC select agents of categories A-C as well as on the Ricketts Regional Biocontainment Laboratory at Argonne National Laboratory, a federal laboratory that is constructed and operated by the University of Chicago for the National Institute of Allergy and Infectious Diseases. The commitment of University of Chicago faculty towards research and training excellence in biodefense and host-pathogen research is reflected in the recent establishment of the Department of Microbiology. Expansive growth with the appointment of seven new faculty over the next five years is accompanied by the recent expansion of graduate training in Microbiology and by the already excellent achievements of faculty and graduate students in this area. Sixteen training faculty study bacterial pathogenesis, animal viruses, viral physiology and pathogenesis, plant pathogenesis, drug resistant microbes, microbial toxins and the immune response to infections. Trainees are selected from a pool of 150 applicants with Bachelor's degree and average GRE and GPA scores of 1375+5 (81%) and 3.3 respectively. The ultimate goals of our training program are ambitious and aim at establishing a premier research program in biodefense and host-pathogen interactions.