Native Alzheimer Disease Resource Center for Minority Aging Research (NAD-RCMAR)

摘要-研究教育部分 在美国，超过600万人患有阿尔茨海默病或相关痴呆症（ADRD）。现存 文献表明，ADRD的风险在少数种族和民族中较高，特别是美国人 印第安人和阿拉斯加原住民（AI/AN）以及夏威夷原住民或太平洋岛民（NHPI）。不幸的是， 缺乏对土著人民ADRD的批判性研究。使用MeSH检索PubMed数据库 “阿尔茨海默病”和“美洲印第安人或阿拉斯加原住民”这两个词只检索到32篇相关出版物， 对NHPI的平行检索仅返回19篇出版物。认可机构/国家机构和国家卫生机构在 NIA资助的阿尔茨海默病研究中心计划，在37名参与者中，45，923名参与者中只有454名 在过去17年中，主要确定为AI/AN或NHPI的中心。因为这些中心的数据 导致一些最有影响力的ADRD研究，AI/AN和NHPI参与者的代表性差， 他们对研究结果、医疗政策或临床治疗标准的贡献有限。 此外，由于很少有AI/AN或NHPI科学家进行ADRD研究。原住民的目标 少数族裔老龄化研究中的阿尔茨海默病资源中心（NAD-RCMAR）旨在建立研究能力， 加强专业劳动力的多样性，培养创新的社会，行为，流行病学， ADRD的临床研究研究教育部分的科学重点将是健康 在AI/AN和NHPI中与ADRD相关的差异，重点关注发生的可改变的风险和弹性因素 在中年和晚年，这都会增加ADRD的风险，并且与AI/AN和NHPI社区高度相关。 REC将通过指导有前途的NAD-RCMAR来增强ADRD研究人员的多样性 科学家，特别是来自代表性不足的少数群体（URM）的科学家，专注于AI/AN和NHPI。所述REC 我们将为NAD-RCMAR科学家提供研究设计和测量方面的支持，并将提供 一个以非常成功的Grantwriting Uncovered：Maximizing Strategies，Help， 机会，经验（GUMSHOE）计划。我们的具体目标是：（1）提供后勤和科学 资源，以支持在人工智能/ANs和NHPI中进行ADRD的创新试点研究， 出版物和随后的赠款申请;（2）增加AI/AN，NHPI和其他URM的数量 开展ADRD研究的调查人员;（3）启动并维持高级管理人员之间的指导关系 研究人员和NAD-RCMAR科学家;（4）提高NAD-RCMAR科学家的方法技能 通过关于研究方法和开展试点研究的教学教育会议;以及（5） 确保试点研究结果发表在高影响力的期刊上，并导致校外资助。关于NAD- RCMAR将要求在ADRD研究中代表AI/AN和NHPI，同时参与早期和中期阶段 职业培训和研究活动的专业人员，这将使他们成为独立的 调查人员，从而丰富和推进这一调查领域，并使劳动力多样化。

ABSTRACT – Research Education Component More than 6 million people in the US have Alzheimer’s disease or related dementias (ADRD). The extant literature suggests that the risk of ADRD are higher among racial and ethnic minorities, especially American Indians and Alaska Natives (AI/AN) and Native Hawaiians or Pacific Islanders (NHPIs). Unfortunately, there is a paucity of critical research on ADRD in Indigenous peoples. A search of the PubMed database using MeSH terms “Alzheimer’s disease” and “American Indian or Alaska Native” retrieved just 32 relevant publications, while a parallel search for NHPIs returned only 19 publications. AI/ANs and NHPIs are also underrepresented in the NIA-funded Alzheimer’s Disease Research Centers Program with only 454 of 45,923 participants in the 37 Centers over the past 17 years primarily identifying as AI/AN or NHPI. Because the data from these Centers lead to some of the most influential ADRD studies, poor representation of AI/AN and NHPI participants assures that they make limited contributions to research findings, healthcare policy or clinical treatment standards. Furthermore, because very few AI/AN or NHPI scientists conduct ADRD research. The goal of the Native Alzheimer’s Disease Resource Center in Minority Aging Research (NAD-RCMAR) is to build research capacity, enhance diversity in the professional workforce, and nurture innovative social, behavioral, epidemiological, and clinical research in ADRD. The scientific focus of the Research Education Component (REC) will be health disparities related to ADRD in AI/ANs and NHPIs by focusing on modifiable risk and resilience factors occurring in mid- and late-life that both increase the risk of ADRD and are highly relevant to AI/AN and NHPI communities. The REC will enhance the diversity of the ADRD research workforce by mentoring promising NAD-RCMAR Scientists especially from underrepresented minority (URM) groups, focusing on AI/ANs and NHPIs. The REC will offer NAD-RCMAR Scientists support in study design and measurement for our Pilot Studies and will deliver a workshop modelled after the highly successful Grantwriting Uncovered: Maximizing Strategies, Help, Opportunities, Experiences (GUMSHOE) program. Our Specific Aims are to: (1) Offer logistical, and scientific resources to support innovative Pilot Studies on ADRD in AI/ANs and NHPIs to generate preliminary data for publications and subsequent grant applications; (2) Increase the number of AI/AN, NHPI, and other URM investigators conducting ADRD research; (3) Initiate and maintain mentoring relationships between senior researchers and NAD-RCMAR Scientists; (4) Improve the methodological skills of NAD-RCMAR Scientists through didactic educational sessions on research methods and their conduct of Pilot Study research; and (5) Ensure Pilot findings are published in high-impact refereed journals and lead to extramural funding. The NAD- RCMAR will require representation of AI/ANs and NHPIs in ADRD studies, while engaging early- and mid-stage professionals in career training and research activities that will prepare them to become independent investigators, thereby enriching and advancing this field of inquiry and diversifying the workforce.