CHIME Research Education Component (REC)

RCMAR CHINE研究教育部分的项目摘要 以领导少数族裔老龄化的发展中科学家20年来非常成功的跟踪记录为基础 研究，研究教育部分(REC)旨在通过支持我们的主题来发展教师 “制定、调整和评估改善种族/少数民族老年人健康的干预措施”， 它包括两个RFA研究目标：i)确定和制定解决方案，以消除健康差距 和日益增长的老年人中的健康不平等，以及二)改善老年人的健康和福祉 上了年纪的人。REC的具体目标是：1)确定、招聘和鼓励URM教师，并展示 研究潜力和对少数群体老龄化研究的兴趣作为RCMAR科学家申请，2)选择，有投入 来自外部顾问的至少3名杰出科学家将获得为期1年的试点研究(每人最高可获得55,000美元 包括加州大学洛杉矶分校的CTSI资金)，3)提供密集的个人指导、教育计划和广泛的 一系列资源，使科学家能够完成、展示和发布他们的研究并最终获得 独立资助，以及4)使用进度报告程序监控科学家的进度， 指导委员会会议，并由CHINE执行委员会(EC)每月简要审查进展情况。 对于这一应用，REC已经确定了3名RCMAR科学家来领导试点项目：1)医学博士Utibe Essien， 公共卫生硕士，加州大学洛杉矶分校普通内科和卫生服务研究助理教授(截至1月 2023)将与导师曼乔内博士合作研究i)种族和民族是否与脆弱有关 有心房颤动(AF)事件的退伍军人；ii)存在的脆弱性是否会影响已知的种族和民族 对发生房颤的退伍军人使用抗凝的不平等；iii)虚弱是否是决定因素 从华法林转向直接口服抗凝治疗。2)李谦，博士，助理 加州大学河滨分校的医学社会学教授将与林克博士和布朗博士合作，研究 50岁后多病的进展，并量化健康差距在 种族/民族和性别的交集是使用健康和退休研究的数据创建的 (HRS，1992-2020)。3)加州大学洛杉矶分校老年病学部临床讲师、MBA、医学博士David Lee将与 Lo和Hays博士使用Kaiser Permanente North California数据来研究痴呆症和 并了解种族和民族的差异，特别是在亚裔美国人和 太平洋岛民亚群。拟议的3个试点涉及社会经济、医疗保健、文化、社会和 心理因素和生理指标跨越四个层次的分析(环境、社会文化、 NIA健康差异研究框架的行为和生物学)(总体参见图1)，以及 将种族/族裔归类为解决健康差距的关键因素。所有三项试点研究都将 提供研究结果，为未来改善老年人健康的干预措施的设计提供参考。2018-23年度， CHINE已经培训了18名科学家，他们发表了154篇论文，并获得了超过1700万美元的资金。

Project Summary for the RCMAR CHIME Research Education Component Building on a highly successful 20-year track record of developing scientists who conduct minority aging research, the Research Education Component (REC) aims to develop faculty by supporting our theme of “Developing, Adapting, and Evaluating Interventions to Improve the Health of Racial/Ethnic Minority Elders”, which incorporates two RFA research objectives: i) identify and develop solutions to eliminate health disparities and health inequities in the growing population of older adults, and ii) improve the health and well-being of older adults. The REC Specific Aims are to: 1) Identify, recruit, and encourage URM faculty with demonstrated research potential and interest in minority aging research to apply as RCMAR scientists, 2) Select, with input from External Advisors, at least 3 outstanding scientists to receive 1-year pilot studies (up to $55,000 each inclusive of UCLA CTSI funds), 3) Provide intensive individual mentorship, an educational plan and a broad array of resources to enable scientists to complete, present, and publish their research and ultimately obtain independent funding, and 4) Monitor the progress of the scientists using a program of progress reports, mentorship committee meetings, and brief monthly progress review by the CHIME Executive Committee (EC). For this application, the REC has identified 3 RCMAR scientists to lead pilot projects: 1) Utibe Essien, MD, MPH, Assistant Professor of General Internal Medicine and Health Services Research, at UCLA (as of Jan 2023) will work with mentor Dr. Mangione to examine i) whether race and ethnicity are associated with frailty in Veterans with incident Atrial Fibrillation (AF); ii) whether the presence frailty influences known racial and ethnic inequities in the use of anticoagulation for Veterans with incident AF; iii) whether frailty is a determinant of switching from warfarin to direct oral anticoagulant therapy for anticoagulation. 2) Chioun Lee, PhD, Assistant Professor of Medical Sociology at UC Riverside, will work with Drs. Link and Brown, to examine the progression of multimorbidity after age 50 and to quantify the mechanisms through which health disparities at the intersection of race/ethnicity and sex are created, using data from the Health and Retirement Study (HRS,1992–2020). 3) David Lee, MBA, MD, Clinical Instructor, Division of Geriatrics at UCLA, will work with Drs. Lo and Hays using Kaiser Permanente Northern California data to study the association of dementia and hip fracture and to understand differences by race and ethnicity, particularly among Asian American and Pacific Islander subgroups. The 3 proposed pilots address socioeconomic, health care, cultural, social, and psychological factors and physiological indicators across four levels of analysis (environmental, sociocultural, behavioral, and biological) of the NIA Health Disparities Research Framework (See Figure 1 in Overall), along with classifying race/ethnicity as a critical factor in addressing health disparities. All three pilot studies will provide findings that inform the design of future interventions to improve the health of older adults. In 2018-23, CHIME has trained 18 scientists who have 154 publications and obtained over $17M in funding.