Integrated Services Core

综合服务核心 摘要： 大学疫苗研究中心(CVR)内的区域生物遏制实验室(RBL) 匹兹堡是感染生物学的生物安全3级(BSL-3)枢纽。RBL的使命有三个方面，即 致力于病原体的出现、进化和宿主间的传播，以研究肺炎的发病机制 新出现的传染病和加快临床前新干预措施和医疗的发展 预防大流行和生物防御的对策。我们的愿景是成为全球公认的、高度- 由感染生物学家组成的协作、创新和前瞻的团队，准备应对新出现的 国家和国际两级的生物威胁。整个工厂都在 选择试剂和毒素(DSAT)。它汇集了来自不同学科的感染生物学家和临床医生。 他们需要BSL-3和动物(A)BSL-3设施来进行广泛的病毒和细菌研究项目。 生物遏制工作操作复杂、基础设施密集、监管全面。正在运行 BSL-3实验室安全、安全、成功地要求有一个组织严密、高度集成的 由管理员、科学家、生物安全/生物安全专业人员、工程师/设施工作人员和 兽医/动物园技术人员。这在多病原体、多用户研究设施中尤其重要 研究标准和筛选试剂BSL-3病原菌。综合服务核心将提供广泛的 为内部用户和外部协作者提供高质量的BSL-3和ABSL-3服务。这些都将严格执行 由学术和服务领导监督，并在外部RBL的协助下每年进行审查 主任、其他BSL-3专家和一个内部科学顾问组。年对RBL的业务支持 匹兹堡将确保我们准备好支持任何国家对一系列新出现的传染病的反应 一旦发生另一场大流行或生物恐怖主义袭击。支持这群BSL-3科学家，他们可以 在紧急情况下研究新的病原体，肯定会有回报。

INTEGRATED SERVICES CORE ABSTRACT: The Regional Biocontainment Laboratory (RBL) within the Center for Vaccine Research (CVR) at the University of Pittsburgh is the biosafety level-3 (BSL-3) hub for infection biology. The mission of the RBL is threefold, to work on pathogen emergence, evolution and host-to-host transmission, to study the pathogenesis of emerging infectious diseases and to accelerate pre-clinical development of novel interventions and medical countermeasures for pandemic preparedness and biodefense. Our vision is to be a globally recognized, highly- collaborative, creative and forward-facing team of infection biologists who are poised to respond to emerging biological threats both at the national and international level. The entire facility is registered with the Division of Select Agents and Toxins (DSAT). It brings together infection biologists and clinicians from a variety of disciplines who require BSL-3 and animal (A)BSL-3 facilities for their wide ranging viral and bacterial research programs. Biocontainment work is operationally complex, infrastructure-dense, and comprehensively regulated. Running BSL-3 laboratories safely, securely and successfully demands having a well-organized and highly integrated team of administrators, scientists, biosafety/biosecurity professionals, engineers/facilities staff and veterinarians/zootechnical staff. This is especially important in multi-pathogen, multi-user research facilities that study standard and select agent BSL-3 pathogens. The Integrated Services Core will deliver a wide range of high quality BSL-3 and ABSL-3 services for internal users and external collaborators. These will be rigorously overseen by Academic and Service Leads and reviewed annually with the assistance of an external RBL Director, other BSL-3 experts and an internal Scientific Advisory Group. Operational support for the RBL in Pittsburgh will ensure we are ready to support any national response to a range of emerging infectious diseases in the event of another pandemic or bioterrorism attack. Supporting this cohort of BSL-3 scientists, who can pivot to work on new pathogens in an emergency, is certain to pay dividends.