Biospecimen Core

摘要-生物样本核心 生物样本核心是获取所有生物样本、验证“正常健康组织”的关键 诊断、处理和分配所需的所有组织和相关生物液体/非组织标本， 气味整合多个成熟的杜克机构，并高度专业化的协作 能力是这个核心的独特优势。我们是国家认可的生物储存库，也是世界上最高的生物储存库之一。 器官移植中心。生物样本库活动与标准治疗同时进行 活组织检查、预定的外科手术、尸检和器官捐献者检查。本核心的目标 是提供具有卓越质量控制措施的生物标本服务， 在整个生命周期（胎儿/围产期到老年人）正常健康组织中的衰老生物标志物。这一核心将 由一个在解剖、器官捐赠和外科组织获取方面具有专门知识的小组领导。完成我们 目标，我们将致力于1）有效地识别，获取和验证高质量正常健康组织的诊断 和并行生物流体/非组织标本的基础上严格的标准，2）处理高质量的正常健康 用于相关分析的组织和3）确保样品管理的质量保证和质量控制， 样本跟踪和生物库信息管理，以实现所有SenNet的最佳库组织共享 资助的机构。我们的长期目标是不断发展，以满足我们的调查人员的需求， 通过法规修改、后勤修改、增加服务菜单或创建解决方案 to challenging挑战research研究problems问题.

ABSTRACT – Biospecimen Core The Biospecimen Core is essential for the acquisition of all biospecimens, verification of “normal healthy tissue” diagnosis, processing and allocation of all tissue and associated biofluids/non-tissue specimens required for SCENT. Integration of multiple, well-established Duke institutions with highly specialized collaborative capabilities is a unique strength of this Core. We are a nationally recognized biorepository and one of the highest organ transplantations centers in the country. Biobanking activities occur in parallel with standard of care biopsies, scheduled surgical procedures, autopsies and organ donor procurements. The objective of this Core is to provide biospecimen services with exceptional quality control measures to enable tissue mapping of cellular senescence biomarkers in normal healthy tissues across the lifespan (fetal/perinatal to elderly). This Core will be led by a team with expertise in autopsy, organ donor and surgical tissue procurement. To accomplish our goals, we will work to 1) efficiently identify, procure and verify diagnoses of high-quality normal healthy tissue and concurrent biofluids/non-tissue specimens based on stringent criteria, 2) process high-quality normal healthy tissues for correlative analyses and 3) ensure quality assurance and quality controls for sample management, specimen tracking and biobanking informatics management for optimal banked tissue sharing for all SenNet funded institutions. Our long-term goal is to constantly evolve to meet the needs of our investigators, either through regulatory modifications, logistical modifications, additions to the service menu, or in creating solutions to challenging research problems.