STORAGE OF NUMOM2B SPECIMENS FOR THE PREGNANCY AND PERINATOLOGY BRANCH OF NICHD

Eunice Kennedy Shriver国家儿童健康和人类发展研究所（NICHD） 建立了无产妊娠结局研究：监测准妈妈（nuMoM 2b），以研究当前妊娠将导致首次分娩的妇女（无产）。在美国，约40%的孕妇患有Nullivalid。由于没有任何信息可从以前的怀孕结果，以指导分配的风险或减轻干预措施，在初产妇的不良妊娠结局是特别不可预测的。不良妊娠结局（如早产、先兆子痫和胎儿生长受限）的潜在机制相互关联，因此将作为本研究的一部分进行评价。 NuMoM 2b研究是一项前瞻性观察性研究，对10，000多名未经产女性进行了从孕早期到分娩的随访，以了解从孕早期开始的不良妊娠结局的机制和病因。在8个临床研究中心进行，包括哥伦比亚大学、印第安纳州大学、凯斯西方大学和俄亥俄州州立大学、位于欧文的加州大学、宾夕法尼亚大学、匹兹堡大学、西北大学和犹他州大学。数据协调中心是三角研究所国际和网络。 所有10，000名参与者的入组于2013年9月完成，最后一名参与者于2014年5月交付。所有研究参与者均接受了一系列评价，包括人口统计学、营养、家族史、母体人体测量、病史、心理社会因素评估、胎儿生长超声测量、胎盘功能（子宫动脉多普勒）和生物样本采集（母体血清、血浆、尿液、宫颈/阴道样本、分娩时胎盘）。

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) established the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) to study women for whom the current pregnancy will lead to their first delivery (nulliparas). Nulliparas comprise about 40% of pregnant women in the United States. Because no information is available from previous pregnancy outcomes to guide assignment of risk or mitigating interventions, adverse pregnancy outcomes in nulliparas are especially unpredictable. The underlying mechanisms of adverse pregnancy outcomes such as preterm birth, preeclampsia, and fetal growth restriction are interrelated, and therefore will be evaluated as part of this study. The NuMoM2b study was a prospective observational study of over 10,000 nulliparous women followed from the first trimester through delivery to understand the mechanism and etiology of adverse pregnancy outcomes starting in the first trimester. It was conducted at eight clinical sites including Columbia University, Indiana University, Case Western and Ohio State Universities, University of California at Irvine , University of Pennsylvania, University of Pittsburgh, Northwestern University, and University of Utah. The data coordinating center was Research Triangle Institute (RTI) International and the Network. Enrollment of all I0,000 participants was completed in September of 2013 and the last participant delivered May 2014. All study participants underwent serial evaluations including demographics, nutrition, family history , maternal anthropometric measurements, medical history, assessments of psychosocial factors, ultrasound measures of fetal growth, placental function (uterine artery Doppler) and biospecimen collection (maternal serum, plasma, urine, cerv ical/vag in al samples, placenta at delivery).