A stable path for a core based scientist to advance imaging and cytometry in basic and preclinical research at the Karmanos Cancer Institute

摘要 这项提案支持核心科学家与我们的癌症中心支持补助金（CCSG）作为 父母补助金，寻求职业稳定性博士Kamiar Moin的显微镜，成像和细胞计数主任 Karmanos癌症研究所（KCI）的资源核心（MICR）。MICR是KCI最大的设施核心， 部分由CCSG资助（P30-CA 022453，Dr.格罗尔德Bepler PI/部门主管; Dr. Moin是共同研究者）。 博士Moin于1994年建立了MICR，作为癌症中心的共聚焦成像核心，并提供切割- 在荧光显微镜、共聚焦显微镜及相关领域的前沿专业知识和最先进的技术 技术.从一开始只有200平方英尺的空间和一个仪器，Moin博士已经扩大， 显著升级了MICR多次，最终成为当前首屈一指的多模式成像， 流式细胞仪服务中心，拥有超过4000平方英尺的空间和22台主要仪器。莫因博士的使命 MICR是支持和加强同行评审资助的研究活动，我们的科学界， 研究需要先进的细胞计数以及细胞、组织和动物成像和分析。履行这一 Moin博士的使命是努力实现以下几个目标：1）提供分析方面的专业知识， 方法开发、技术开发和验证、成像和细胞计数研究设计; 2） 为赠款提案和出版物提供合作和咨询; 3）提供和维护 流式细胞术、显微镜和成像方面先进仪器; 4）促进 我们的科学成员之间的方案内和方案间互动的机会; 5）尽量减少 成本和努力，同时提高效率和6）提供教育和培训 在显微镜、成像和流式细胞术方面的机会。Moin博士是一位国内和国际 公认的成像和细胞计数专家和领导者，他在18个NIH研究部门的服务证明了这一点， 众多的演讲和研讨会，拥有超过30年的经验和超过二十年的设施 核心管理和行政技能。他在成像和细胞计数方面的专业知识， 在技术和方法的发展是至关重要的CCSG和25个国家癌症研究所资助的发起 利用MICR的研究项目。这个应用程序，如果资助，将支持100%他的努力，并将抵消一些 通过降低收费率，降低国家癌症研究所资助项目的成本。R50将 提供职业稳定性，而不依赖于个人补助金，并允许他优先考虑他的努力 这些项目需要方法和技术开发。请拨的旅费将 使Moin博士能够参加成像和细胞计数会议和/或核心设施管理会议， 作为生物分子研究设施协会（ABRF），继续他的教育， 成像/细胞计数和核心管理，以有效地发挥他的作用，以支持NCI资助的项目。

Abstract This proposal support for a core-based scientist with our Cancer Center Support Grant (CCSG) as the parent grant, seeks career stability for Dr. Kamiar Moin the Director of the Microscopy, Imaging and Cytometry Resources core (MICR) of the Karmanos Cancer Institute (KCI). MICR is the largest facility core of KCI and is funded, in part, by the CCSG (P30-CA022453, Dr. Gerold Bepler PI/Unit Director; Dr. Moin is a co-investigator). Dr. Moin established MICR in 1994 as the Confocal Imaging Core in the Cancer Center and provided cutting- edge expertise and state-of-the-art technology in fluorescent microscopy, confocal microscopy and related techniques. From the beginning with only a 200 ft2 space and one instrument, Dr. Moin has expanded and significantly upgraded the MICR a number of times culminating into the current premier multimodal imaging and flow cytometry service center with over 4000 ft2 space and 22 capital instruments. Dr. Moin’s mission through MICR is to support and enhance the peer reviewed funded research activities of our scientific community whose research requires advanced cytometry as well as cellular, tissue, and animal imaging and analysis. To fulfill this mission, Dr. Moin strives to consistently meet several objectives, which are to: 1) provide expertise in analytical methods development, technology development and validation, imaging and cytometry study design; 2) provide collaboration and consultation for grant proposals and publications; 3) provide and maintain state-of-the-art advanced instrumentation in flow cytometry, microscopy and imaging; 4) promote opportunities for intra- and inter-programmatic interaction among our scientific members; 5) minimize cost and effort for KCI investigators while increasing efficiency and 6) provide educational and training opportunities in microscopy, imaging and flow cytometry. Dr. Moin is a nationally and internationally recognized expert and leader in imaging and cytometry, evident by his service on 18 NIH study sections and numerous presentations and workshops, with over 30 years of experience and more than two decades of facility core management and administrative skills. His expertise in imaging and cytometry with a proven track record in technology and methods development is critical to the CCSG and the 25 NCI funded investigator-initiated research projects utilizing MICR. This application, if funded, will support 100% of his efforts and will offset some of the costs incurred by the individual NCI funded projects by reducing the chargeback rates. The R50 will provide career stability without dependence on individual grant and allows him to prioritize his effort on those projects that require methodology and technology development. The funds requested for travel will enable Dr. Moin to attend conferences in imaging and cytometry and/or core facility management meetings such as the Association of the Biomolecular Research Facilities (ABRF), to continue his education in imaging/cytometry and core management to be effective in his role to support the NCI funded projects.