West Virginia Clinical and Translational Science Institute: Improving Health through Partnerships and Transformative Research

近年来，与死亡率下降相反，阿巴拉契亚的死亡率逐渐上升 在美国其余地区观察到的利率。西弗吉尼亚州在美国50个州中排名第47位。 2015年美国健康排名此外，WV仍然处于或接近底部，为一些慢性 包括癌症和心血管疾病。这些观察本身并不能反映整个 国家或地区面临一系列与健康有关的挑战，但明确强调需要继续关注 并投资于支持真实的解决方案的研究。西弗吉尼亚临床和翻译 科学研究所（WVCTSI）成立于2012年，通过最初的临床和转化研究（CTR） 奖励，并随后形成了一个良好的连接，全州范围内的研究网络，创造了基础设施 解决西弗吉尼亚州存在的巨大健康差距。WVCTSI的首要目标是 作为一个协作中心，引领全州范围内的临床和转化研究创新，催化和 加快制定解决棘手健康问题的办法。在过去的四年里，WVCTSI一直是一个 改革力量，落实调查员辅导服务，建立试点项目资金，组建 一个由68个站点（大部分是农村）组成的基于实践的研究网络，创建了一个200万人的综合数据库 独特的电子病历，发展一种基础广泛的研究诚信文化，并与我们的 合作伙伴建立信任和有效合作。WVCTSI现在已经做好了实现这一目标的准备。 更新申请包括：1）建立可持续的研究基础设施， 到2022年改善西弗吉尼亚州的健康结果，2）招募下一代临床科学家和翻译 擅长团队科学并致力于长期成功的研究人员，以及3）积极参与 多个利益相关者，包括社区，医疗提供者和政策制定者，以推动研究， 改善西部居民的健康状况。我们的合作伙伴还包括该州所有的学术医疗中心 如肯塔基州大学、退伍军人管理局和国家职业安全研究所 与健康通过其集体活动和强有力的伙伴关系，WVCTSI将在以下方面发挥关键作用： 扭转了西弗吉尼亚州死亡率上升的趋势，并作为发展有效的 为区域卫生问题提供解决方案的研究基础设施。

Mortality rates in Appalachia have progressively increased over recent years, in contrast to decreasing mortality rates observed in the remainder of the US. West Virginia was ranked 47th overall among the 50 states in the 2015 America's Health Rankings. In addition, WV remains at, or near, the bottom for a number of chronic diseases including cancer and cardiovascular disease. These observations alone do not capture the entire continuum of health related challenges in the state or region, but clearly emphasize the need for continued focus on, and investment in, research that underpins real solutions. The West Virginia Clinical and Translational Science Institute (WVCTSI) was created in 2012 through the initial Clinical and Translational Research (CTR) award and has subsequently formed a well-connected, statewide research network, creating the infrastructure to address the substantial health disparities that exist in West Virginia. The overarching goal of the WVCTSI is to serve as a collaborative hub to lead statewide innovation in clinical and translational research, catalyzing and accelerating development of solutions to vexing health problems. Over the past four years, WVCTSI has been a transformative force, implementing investigator mentoring services, establishing pilot project funding, forming a practice-based research network of 68 sites (mostly rural), creating an integrated data repository of two million unique electronic medical records, developing a broad-based culture of research integrity, and working with our partners to establish trust and effective collaboration. WVCTSI is now well positioned to attain the goals of this renewal application that include: 1) building sustainable research infrastructure that substantively contributes to improving WV health outcomes by 2022, 2) recruiting the next generation of clinician scientists and translational researchers that excel in team science and are positioned for long-term success, and 3) actively engaging with multiple stakeholders that include communities, medical providers, and policy makers to drive research that improves health of West Virginians. Our partners include all academic medical centers within the state as well as the University of Kentucky, the Veterans Administration, and the National Institute for Occupational Safety and Health. Through its collective activities and powerful partnerships, the WVCTSI will play a critical role in reversing the trend of increasing mortality rates in West Virginia and serve as a model for developing effective research infrastructure that provides solutions to regional health issues.