Redox homeostasis in cancer and cardiovascular diseases

我们以前的研究表明，线粒体功能障碍会导致DNA氧化损伤，并有助于肿瘤的发生。一个主要的因素是环境氧，它是产生可造成生物损害的活性氧物种的基本底物。环境和遗传方法将被用来调节氧化还原动态平衡，并确定它们对能量代谢、肿瘤发生和心血管功能的影响。我们还在研究细胞在氧化或其他细胞应激条件下生存的适应机制。我们最近已经证明了保持线粒体DNA对预防阿霉素引起的心肌病的重要性，并正在考虑在其临床表现之前预防疾病的新策略。

Our previous studies have suggested that mitochondrial dysfunction causes oxidative DNA damage and contributes to tumorigenesis. A major contributing factor is ambient oxygen which is the essential substrate for reactive oxygen species generation that can cause biological damage. Environmental and genetic methods will be used to modulate redox homeostasis and to determine their effect on energy metabolism, tumorigenesis, and cardiovascular function. We are also examining the adaptive mechanisms by which cells can survive under oxidative or other cellular stress conditions. We have recently demonstrated the importance of maintaining mtDNA to prevent doxorubicin-induced cardiomyopathy and are considering new strategies for disease prevention prior to its clinical manifestation.