Visual control of locomotion in people with Parkinsons disease

步态障碍是帕金森氏症的一个核心特征，患者变得更加依赖视觉来补偿他们的运动缺陷。然而，视觉障碍是帕金森氏症的一个常见但经常被忽视的问题，可能会导致不安全的运动。为了有效地在复杂的现实世界环境中导航，眼球运动需要与运动任务相协调。行走和转身过程中的凝视预测是运动预测的关键，也是运动过程中空间知觉的重要组成部分。这个项目的总体目标是描述凝视是如何被衰减到环境的不同方面，以及在复杂的现实世界环境中行走时视觉功能如何与动态稳定性相关。具体目的是：1.确定路径复杂性对运动视觉控制的影响。研究用药状态对运动视觉控制的影响。研究认知与运动视觉控制的关系。在技术进步的基础上，该项目旨在确定在复杂的现实世界环境中，视觉功能和认知对帕金森氏症患者步态结果的贡献，目的是为未来的干预提供信息。

Gait impairments are a core feature in Parkinson’s disease and patients become more visually dependent to compensate for their motor deficits. Yet, visual disturbances are a common, but often overlooked problem in Parkinson’s disease, that may lead to unsafe locomotion. To navigate efficiently through complex real-world environments, eye movements need to be attuned to the locomotor task. Gaze anticipation during walking and turning is critical for motor anticipation, and contributes to the spatial perception during motion. The overall goal of this project is to characterize how gaze is attenuated to different aspect of the environment and how visual function relates to dynamic stability during walking in complex real-world settings. The specific aims are: I. To determine the effect of path complexity on visual control of locomotion. II. To determine the effect of medication state on visual control of locomotion. III. To investigate how cognition is related to visual control of locomotion. Building upon technological advances, this project aims to determine the contribution of visual function and cognition on gait outcomes in people with Parkinson's disease in complex real-world settings with the goal to inform future interventions.