Caribbean, Central and South America Network for HIV Epidemiology (CCASAnet)

项目总结/摘要 加勒比、中美洲和南美洲艾滋病毒流行病学网络（CCASAnet）是一个已建立的网络， 国际流行病学数据库评估艾滋病（leDEA）计划内的生产网络。 CCASAnet于2006年在第一个leDEA资助周期期间创建， 太子港艾滋病毒临床护理和研究地点的统计、流行病学和信息学资源， 海地;墨西哥墨西哥城;洪都拉斯特古西加尔帕;秘鲁利马;阿根廷布宜诺斯艾利斯;智利圣地亚哥;以及 巴西里约热内卢、贝洛奥里藏特和圣保罗，沿着设有一个协调中心，位于美国纳什维尔。 CCASAnet协作的成员共同应对该区域出现的科学机会 以及全球艾滋病研究网络。位于范德比尔特的CCASAnet数据协调中心 大学（VDCC）管理CCASAnet联盟，并致力于协调和分析复杂的 参与研究中心生成的数据库。VDCC还提供指导和教育， CCASAnet网站的临床研究和数据管理能力，促进初级研究人员， 促进该地区科学领导力的持续增长。在今后五年中，CCASAnet将评估 本区域与艾滋病毒感染和抗逆转录病毒治疗有关的临床结果和并发症，以及 确定艾滋病毒以外的感染的影响，特别是结核病、肝炎、人乳头瘤病毒， 和登革热。CCASAnet研究将调查癌症和心脏病等非传染性疾病 艾滋病毒流行病的区域趋势及其对弱势群体的影响，以及 对拉丁美洲的公共卫生至关重要。此外，研究将探讨与儿童独特相关的因素， 青少年和年轻的艾滋病毒感染者。我们将继续开发和应用创新的生物统计学， 信息学方法，发展我们与其他IeDEA地区的富有成效的合作，并在以下方面提供领导 现场评估和数据统一举措。通过这些活动，CCASAnet3.0将有助于 推动艾滋病毒流行病学和信息科学的发展， 研究合作。

PROJECT SUMMARY/ABSTRACT The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) is an established and productive network within the International epidemiologic Databases to Evaluate AIDS (leDEA) program. CCASAnet was created in 2006 during the first leDEA funding cycle and has brought together clinical, statistical, epidemiologic, and informatics resources from HIV clinical care and research sites in Port-au-Prince, Haiti; Mexico City, Mexico; Tegucigalpa, Honduras; Lima, Peru; Buenos Aires, Argentina; Santiago, Chile; and Rio de Janeiro, Belo Horizonte, and Sao Paulo, Brazil, along with a coordinating center in Nashville, USA. Together, the members of the CCASAnet collaboration respond to scientific opportunities arising in the region and across HIV research networks worldwide. The CCASAnet Data Coordinating Center at Vanderbilt University (VDCC) manages the CCASAnet consortium and works to harmonize and analyze the complex databases generated by participating sites. The VDCC also provides mentoring and education to enhance clinical research and data management capabilities at CCASAnet sites, promote junior researchers, and catalyze ongoing growth of scientific leadership in the region. Over the next five years, CCASAnet will evaluate clinical outcomes and complications related to HIV infection and antiretroviral therapy in the region, and determine the impact of infections other than HIV, particularly tuberculosis, hepatitis, human papillomavirus, and dengue. CCASAnet studies will investigate non-communicable diseases such as cancer and heart disease, regional trends in the HIV epidemic and its impact on vulnerable populations, and other issues of public health importance in Latin America. Additionally, studies will address factors uniquely related to children, adolescents, and young adults with HIV. We will continue to develop and apply innovative biostatistics and informatics methods, grow our productive collaborations with other IeDEA regions, and provide leadership in the site assessment and data harmonization initiatives. Through these activities, CCASAnet 3.0 will help advance both the science of HIV epidemiology and the information science that underpins international research collaboration.