WOMEN RESILIENCE TO TRAUMA: FMRI STUDY OF EMOTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本项目主要目标是为赠款提案获得试验数据。该补助金的目标是了解经历过性创伤或亲密伴侣暴力的女性的情绪区域大脑控制。具体而言，该项目将比较在遭受创伤后表现出复原力的妇女（表现为在工作、人际关系和享受生活方面保持功能）与表现出功能障碍并发展为创伤后应激障碍的妇女。 fMRI BOLD反应将被用来探索是否弹性极端压力的负面后果将与减少杏仁核和增强内侧前额叶皮质功能的fMRI成像任务，旨在评估这些大脑结构的反应。我们建议在fMRI中使用四个任务。1)认知重新评估任务已经被证明可以激活前额叶皮层。在这项任务中，受试者被要求观看旨在引起情绪中立，消极和积极反应的图片。他们还将被要求在磁铁中增强和抑制这些情绪。2)我们还将使用一项任务，让受试者接触不同强度的情绪面孔，向他们展示恐惧，愤怒和中性的面孔。这项任务已经被证明可以激活杏仁核。3)我们将采用奖励激励任务，其中受试者在不同的条件下玩电脑游戏，有可能赢得或失去少量的钱。4)最后，他们将在一项任务中接受功能性磁共振成像研究，在这项任务中，他们将被告知，在观看特定图像时，他们将受到不舒服但不是非常痛苦的电击，而在其他条件下，他们将是“安全的”。实际上，不会产生电击。最后，我们将探讨与积极情绪/乐观，认知灵活性（包括积极重新评价的能力），道德指南针（包括精神和宗教依恋的措施），社会支持和积极应对领域的功能弹性相关的心理社会因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The principal goal of this project is obtain pilot data for a grant proposal. The goal of the grant is to understand the regional brain control of emotion in women who have experienced sexual trauma or intimate partner violence. Specifically, the project will compare women who demonstrate resiliency after traumatic exposure (as evidenced by the maintenance of function in the domains of work, interpersonal relationships and enjoyment of life) to those who show functional impairment and develop PTSD. fMRI BOLD response will be used to explore whether resilience to the negative consequences of extreme stress will be related to reduced amygdala and enhanced medial prefrontal cortex function in response to fMRI imaging tasks designed to evaluate these brain structures. We propose to use four tasks during fMRI. 1) A cognitive reappraisal task has been shown to activate the prefrontal cortex. In this task, subjects are asked to view pictures designed to elicit emotionally neutral, negative and positive responses. They will also be asked to enhance and suppress those emotions while in the magnet. 2) We will also be using a task exposing subjects to different intensities of emotional faces, showing them fearful, angry and neutral faces. This task has been shown to activate the amygdala. 3) We will employ a reward incentive task in which subject play a computer game under different conditions with the potential to win or lose small amounts of money. 4) Lastly, they will be studied with fMRI during a task in which they will be told that they will be given an uncomfortable but not extremely painful electric shock, while viewing specific images, while under other conditions they will be "safe'. In actuality, no shock will be delivered. Finally we will explore psychosocial factors associated with functional resilience in the domains of positive emotions/optimism, Cognitive flexibility (including the capacity for positive reappraisal), moral compass (including measures of spirituality and attachment to religion), social support and active coping.