A stable path for a core based scientist to advance imaging and cytometry in basic and preclinical research at the Karmanos Cancer Institute

摘要 这项提案支持一位核心科学家，我们的癌症中心支持补助金(CCSG)作为 家长资助，为显微镜、成像和细胞测量学主任Kamiar Moin博士寻求职业稳定 卡尔马诺斯癌症研究所(KCI)资源核心(MICR)。MICR是KCI最大的设施核心和IS 部分资金由协调小组提供(P30-CA022453，Gerold Bepler Pi/股长；Moin博士是联合调查员)。 Moin博士于1994年建立了MICR，作为癌症中心的共焦成像核心，并提供切割- 荧光显微镜、共聚焦显微镜及相关领域的前沿专业知识和最新技术 技巧。从一开始只有200英尺2的空间和一台仪器，莫因博士已经扩展了 MICR进行了多次重大升级，最终形成了当前首屈一指的多模式成像和 拥有4000多平方英尺空间和22台首都仪器的流式细胞仪服务中心。莫因博士的任务通过 MICR将支持和加强由同行评审资助的我们科学界的研究活动，其 研究需要先进的细胞术以及细胞、组织和动物的成像和分析。为了实现这一点 在这项使命中，莫因博士一直致力于实现以下几个目标：1)提供分析方面的专业知识 方法开发、技术开发和验证、影像和细胞学研究设计；2) 为赠款提案和出版物提供协作和咨询；3)提供和维护 在流式细胞仪、显微镜和成像方面拥有最先进的仪器；4)促进 我们科学成员之间方案内和方案间互动的机会；5)最大限度地减少 KCI调查员的成本和精力，同时提高效率和6)提供教育和培训 在显微镜、成像和流式细胞术方面的机会。莫因博士是一位国内和国际的 在成像和细胞学方面是公认的专家和领导者，他在18个NIH研究部门和 有30多年的经验和20多年的设施，有许多演讲和研讨会 核心管理和行政技能。他在成像和细胞学方面的专业知识和良好的记录 在技术和方法方面，开发对CCSG和NCI资助的25名研究人员来说是至关重要的 利用MICR的研究项目。这项申请，如果得到资助，将100%支持他的努力，并将抵消一些 NCI通过降低退款费率资助的个别项目的成本。R50将 在不依赖个人补助的情况下提供职业稳定性，并允许他优先考虑 那些需要方法和技术开发的项目。为旅费申请的资金将 使Moin博士能够参加成像和细胞学会议和/或核心设施管理会议，如 作为生物分子研究设施协会(ABRF)，继续他的教育 成像/细胞仪和核心管理将有效地发挥他的作用，支持NCI资助的项目。

Abstract This proposal support for a core-based scientist with our Cancer Center Support Grant (CCSG) as the parent grant, seeks career stability for Dr. Kamiar Moin the Director of the Microscopy, Imaging and Cytometry Resources core (MICR) of the Karmanos Cancer Institute (KCI). MICR is the largest facility core of KCI and is funded, in part, by the CCSG (P30-CA022453, Dr. Gerold Bepler PI/Unit Director; Dr. Moin is a co-investigator). Dr. Moin established MICR in 1994 as the Confocal Imaging Core in the Cancer Center and provided cutting- edge expertise and state-of-the-art technology in fluorescent microscopy, confocal microscopy and related techniques. From the beginning with only a 200 ft2 space and one instrument, Dr. Moin has expanded and significantly upgraded the MICR a number of times culminating into the current premier multimodal imaging and flow cytometry service center with over 4000 ft2 space and 22 capital instruments. Dr. Moin’s mission through MICR is to support and enhance the peer reviewed funded research activities of our scientific community whose research requires advanced cytometry as well as cellular, tissue, and animal imaging and analysis. To fulfill this mission, Dr. Moin strives to consistently meet several objectives, which are to: 1) provide expertise in analytical methods development, technology development and validation, imaging and cytometry study design; 2) provide collaboration and consultation for grant proposals and publications; 3) provide and maintain state-of-the-art advanced instrumentation in flow cytometry, microscopy and imaging; 4) promote opportunities for intra- and inter-programmatic interaction among our scientific members; 5) minimize cost and effort for KCI investigators while increasing efficiency and 6) provide educational and training opportunities in microscopy, imaging and flow cytometry. Dr. Moin is a nationally and internationally recognized expert and leader in imaging and cytometry, evident by his service on 18 NIH study sections and numerous presentations and workshops, with over 30 years of experience and more than two decades of facility core management and administrative skills. His expertise in imaging and cytometry with a proven track record in technology and methods development is critical to the CCSG and the 25 NCI funded investigator-initiated research projects utilizing MICR. This application, if funded, will support 100% of his efforts and will offset some of the costs incurred by the individual NCI funded projects by reducing the chargeback rates. The R50 will provide career stability without dependence on individual grant and allows him to prioritize his effort on those projects that require methodology and technology development. The funds requested for travel will enable Dr. Moin to attend conferences in imaging and cytometry and/or core facility management meetings such as the Association of the Biomolecular Research Facilities (ABRF), to continue his education in imaging/cytometry and core management to be effective in his role to support the NCI funded projects.