Northwestern/Nigeria Research Training Program in HIV and Malignancies (NN-HAM)

项目摘要 西北/尼日利亚艾滋病毒和艾滋病研究培训计划（NN-HAM）解决了一个高风险的问题。 由于艾滋病毒的广泛传播，美国国立卫生研究院的优先研究领域和撒哈拉以南非洲的重大问题 致癌病毒合并感染的高负担使流行病变得更糟。抗逆转录病毒治疗项目 由PEPFAR、全球基金和其他机构实施的艾滋病毒/艾滋病紧急救援计划， 发病率和死亡率;然而，随着人口老龄化，某些恶性肿瘤的发病率正在上升。最 非洲的医疗和研究机构对应对这些新出现的挑战准备不足。自2014年以来， 西北大学和尼日利亚乔斯大学成功合作开展了一项研究培训 艾滋病毒和恶性肿瘤计划（西北和乔斯大学艾滋病毒和 恶性肿瘤，D43 TW 009575）。课程亮点包括：2个硕士学位水平的临床研究 培训了科学家和2名卫生服务和成果研究博士;高级教师进修;以及6名 飞行学员奖励。我们进一步与西北大学、拉各斯大学和 乔斯大学成功竞争NCI资助的U 54（艾滋病毒相关的表观基因组生物标志物） 尼日利亚的癌症，1U 54 CA 221205）。本次更新福格蒂艾滋病毒研究培训计划的中低收入国家 一项提案将进一步提高尼日利亚科学家进行大规模人群艾滋病毒恶性肿瘤研究的能力 通过培训专注于癌症分子流行病学的科学家。我们的主要假设是 在HIV相关恶性肿瘤的分子癌症流行病学、生物统计学和生物信息学方面的能力 将显著增强我们对癌症流行病学的理解，并促进基于生物标志物的机制 研究将为预防和治疗策略提供信息，最终导致癌症减少 发病率和死亡率。本续期申请的具体目的是：1.训练癌分子 流行病学家能够：i）设计和进行基于人群的分子流行病学研究，ii） 开发用于生物样本收集、处理和储存的方案，以及iii）开发生物标记物，所述生物标记物 可用于预防和改善HIV相关恶性肿瘤的治疗; 2.培养多名硕士 学位水平的生物统计学家和科学家在医学信息学和生物信息学谁可以管理和 处理来自临床、实验室和人群环境的数据，并进行全面的生物统计和 由大群体研究产生的生物信息学分析;以及3.创建多学科研究团队 能够进行先进的国内分子流行病学研究，包括高通量“组学” 在我们的网络站点乔斯大学和拉各斯大学开展艾滋病毒相关恶性肿瘤研究。我们 我将通过强有力的指导和研究培训，包括实现我们的目标：1博士学位和4个硕士学位 学位（长期），3个中期研究项目驱动的培训方案，几个短期国内 创新的远程教育。

PROJECT SUMMARY The Northwestern/Nigeria Research Training Program in HIV and Malignancies (NN-HAM) addresses a high priority NIH research area and significant problem in sub-Saharan Africa because of the widespread HIV epidemic made worse by the high burden of oncogenic viral co-infections. Antiretroviral therapy programs put into place by PEPFAR, the Global Fund and others, have resulted in a remarkable decrease in HIV-related morbidity and mortality; however, the rate of certain malignancies are rising while the population is aging. Most African medical and research institutions are ill-prepared to confront these emerging challenges. Since 2014, Northwestern University and University of Jos in Nigeria successfully collaborated in a research training program for HIV and malignancies (Northwestern and Jos University Research Training Program in HIV and Malignancies, D43 TW009575). Program highlights include: 2 master's degree-level Clinical Investigation scientists and 2 PhDs in Health Services & Outcomes Research trained; senior faculty enrichment; and 6 mentored trainee pilot awards. We further formed a network with Northwestern, University of Lagos, and University of Jos to successfully compete for an NCI-funded U54 (Epigenomic Biomarkers of HIV-Associated Cancers in Nigeria, 1U54CA221205). This renewal Fogarty HIV Research Training Program for LMICs proposal will further enhance Nigerian scientists' capacity for large population-based HIV-malignancy research by training scientists focused on cancer molecular epidemiology. Our primary hypothesis is that building capacity in molecular cancer epidemiology, biostatistics, and bioinformatics on HIV-associated malignancies will significantly enhance our understanding of cancer epidemiology and promote mechanistic biomarker-based research that will inform preventive and therapeutic strategies, ultimately leading to a reduction in cancer incidence and mortality. This renewal application's specific aims are to: 1. train cancer molecular epidemiologists capable of: i) designing and conducting population-based molecular epidemiology studies, ii) developing protocols for biospecimen collection, processing, and storage, and iii) developing biomarkers that can be used for prevention and improved treatment of HIV-associated malignancies; 2. train several master's degree-level biostatisticians and scientists in medical informatics and bioinformatics who can manage and handle data from clinical, laboratory, and population settings, and perform comprehensive biostatistical and bioinformatic analyses generated from large population studies; and 3. create a multidisciplinary research team capable of performing advanced in-country molecular epidemiology research, including high throughput “omic” research, on HIV-associated malignancies at our network sites, University of Jos and University of Lagos. We will achieve our goals through strong mentorship and research training including: 1 PhD degree and 4 master's degrees (long-term), 3 medium-term research-project-driven training programs, several short-term in-country workshops, and innovative distance learning.