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Dermatology Consultation Service

Dermatology Consultation Service
皮肤科咨询服务
批准号:
10262802
负责人:
Edward Cowen
金额:
$1.09万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
AcademyAdverse reactionsAmericanAngiogenesis InhibitorsAtrial myxoma with lentiginesAwardBehcet SyndromeBirt-Hogg-Dube SyndromeBronchiolitis ObliteransCatalogsChronic Granulomatous DiseaseClinicalClinical ResearchClinical Research ProtocolsClinical TrialsCollaborationsCommunitiesCongressesConsultConsultationsCountryCutaneousDermatofibrosarcomaDermatologicDermatologyDiagnosisDiseaseDoseEnrollmentEpidermal Growth Factor ReceptorErlotinibEtiologyFeverFolliculitisGoalsHamartomaHereditary Malignant NeoplasmHeritabilityHomologous TransplantationImmuneImmunologic Deficiency SyndromesInflammatoryInheritedInstitutesInterdisciplinary StudyInterleukin-1Interleukin-1 ReceptorsInterleukin-12Job&aposs SyndromeLeiomyomaLesionLymphomaMalignant NeoplasmsManuscriptsMedicineModalityNational Human Genome Research InstituteNational Institute of Allergy and Infectious DiseaseNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of Neurological Disorders and StrokeNatural HistoryNurse PractitionersPalmar-plantar erythrodysesthesia syndromePatientsPennsylvaniaPeriodicityPhasePrincipal InvestigatorProtocols documentationPublishingReactionRenal Cell CarcinomaResearch PersonnelResearch SupportRestRheumatologyServicesSkinSocietiesSyndromeSystemic diseaseTextTherapeuticTherapeutic TrialsTransplantationUnited States National Institutes of HealthVariantWiskott-Aldrich Syndromeadenosine deaminase deficiencyanakinraautoinflammatorybasebevacizumabchronic graft versus host diseasecongenital immunodeficiencyexperiencegraft vs host diseaseinterestlecturesleukemia/lymphomamontelukastpomalidomideresponseside effectskin disorderskin lesiontherapeutic evaluation

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中文摘要
翻译
咨询服务人员主要包括我本人、John DiGiovanna博士和2011年加入该科的护士从业人员Olanda Hathaway。如上所述,在皮肤病的评估和管理方面提供临床专业知识是对NIH社区的一项高度重视的服务,这一点在2007年获得了NIH主任奖的认可。除了咨询病人外,我还是其他分支机构发起的其他几个方案的副研究员,以及三个治疗方案的首席研究员(将另行讨论)。我目前作为副研究员参与的非皮肤科方案包括:GVHD的自然病史;恶性淋巴瘤/白血病的降低强度移植;免疫耗竭治疗和非亲属捐赠者的降低强度移植;DOCK8免疫缺陷的异基因移植;泊马度胺用于慢性GVHD;孟鲁司特治疗毛细支气管炎闭塞性肺病;埃洛替尼和贝伐单抗治疗肾细胞癌;自身炎症性疾病的自然病史;白塞病的Anakinra;IL-1拮抗剂缺乏的利洛那普。慢性移植物抗宿主病(GVHD)的合作工作是与NCI和非NCI研究GVHD自然病史的几个NCI和非NCI的主要多学科合作。根据我在这个小组的经验,我已经出版了几个关于皮肤GVHD的文本章节和临床手稿,并有幸在全国各地的不同组织(哈佛大学、塔夫茨大学、宾夕法尼亚大学、美国皮肤病学会、地区性皮肤病学会和世界皮肤病大会)演讲。通过繁忙的咨询服务,协作临床研究非常活跃。
英文摘要
The Consult Service Staff consists primarily of myself, Dr. John DiGiovanna and a Nurse Practitioner, Olanda Hathaway, who joined the Branch in 2011. As mentioned above, providing clinical expertise in the assessment and management of the cutaneous disease is a highly valued service to the NIH community which was recognized by the NIH Director's Award in 2007. In addition to seeing patients in Consultation, I am an Associate Investigator on several other protocols initiated by other branches as well as a Principal Investigator on three therapeutic protocols (to be discussed separately). The current non-Dermatology Branch protocols in which I am an Associate Investigator include Natural History of GVHD; Reduced intensity transplants for malignant lymphomas/leukemias; Immune-depleting therapy and reduced intensity transplant using unrelated donors; Allogeneic transplant for DOCK8 Immunodeficiency; Pomalidomide for chronic GVHD; Phase II Montelukast for bronchiolitis obliterans; Erlotinib and bevacizumab for renal cell carcinoma; Natural history of auto-inflammatory diseases; Anakinra for Behcet's disease; Rilonacept for deficiency of the IL-1 antagonist. The chronic graft versus host disease (GVHD) collaborative effort is a major multidisciplinary collaboration with several NCI and non-NCI investigators studying the Natural history of GVHD. Based on my experience with this group, I have published several text chapters and clinical manuscripts on cutaneous GVHD and have been honored to lecture to various groups around the country (Harvard, Tufts, U. of Pennsylvania, the American Academy of Dermatology, regional dermatologic societies, and the World Congress of Dermatology.) Collaborative clinical research is extremely active via the busy consultation service.
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Chronic graft-versus-host disease
Anakinra for neutrophilic pustular skin disease
Dermatology Consultation Service
Dermatology Consultation Service
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