Biostatistics and Database Core

生物统计和数据库核心E是这项计划项目赠款(PPG)的一个组成部分 复杂综合征：利用网络了解TDP相关额颞部退行性变的异质性 宾夕法尼亚大学(宾夕法尼亚大学)佩雷尔曼医学院(PSOM)。核心E的目标 是为了支持数据管理、数据库、统计、生物信息学和相关的计算需求 PPG调查员。Core E提供的服务包括：(A)支持数据表格/调查问卷设计 和开发、数据库开发和管理、数据录入、数据库审计跟踪、数据库安全、 数据库备份和严格的数据质量控制程序，(B)为所有人提供计算和编程支持 PPG活动，包括实施和整合必要的硬件和软件升级 数据管理和研究、PPG核心计算系统的日常和存档异地备份， (C)从开始到出版，为项目和核心研究的所有方面提供生物统计支助，包括 开发研究设计，执行样本量和功率计算，并执行以下分析 PPG数据，(D)与神经成像核心C合作支持图论分析，(E) 开发新的统计方法，并在需要时扩展现有方法 对PPG数据的分析，因此，核心E发挥着重要和重要的作用，这对 在PPG的研究和研究的进行。

The Biostatistics and Database Core E is an integral part of this program project grant (PPG) “From cells to complex syndromes: Using networks to understand heterogeneity in TDP-related frontotemporal degeneration and aging” at the University of Pennsylvania (Penn) Perelman School of Medicine (PSOM). The goal of Core E is to support the data management, database, statistics, bioinformatics, and related computational needs of the PPG investigators. The services provided by Core E include: (a) support for data form/questionnaire design and development, database development and management, data entry, database audit trail, database security, database backup, and stringent data quality control procedures, (b) computing and programming support for all PPG activities, including implementation and integration of hardware and software upgrades necessary for data management and research, routine and archival off-site backup of computing systems central to the PPG, (c) biostatistical support for all study aspects of Projects and Cores from inception to publication, including development of study design, performing sample size and power calculations, and performing analyses of the PPG data, (d) support graph theoretic analysis in collaboration with the Neuroimaging Core C, (e) development of new statistical methodologies and extension of existing methodologies where needed for analyses of the PPG data, Thus, Core E plays an important and significant role that is critical to the progress of research and the conduct of studies in the PPG.