Translational Hearing Center

项目摘要/摘要 翻译听证中心总体规划 这个生物医学研究卓越中心(COBRE)的申请是建立翻译听证会 中心，由位于中心位置的克雷顿大学管理，与男童镇国家研究医院 (BTNRH)和内布拉斯加大学医学中心(UNMC)作为机构合作伙伴。我们的总体目标是 建立一大批学术翻译研究人员，开发治疗干预措施，以保存或 从导致听力损失和前庭的各种原因恢复听力和前庭功能 赤字。婴儿和儿童听力损失导致听力和口语技能的延迟获得 对受影响个人的学业成就和最大职业发展轨迹至关重要。在老龄化的人口中， 听力损失和前庭缺陷如果没有适当的康复措施，会加速衰老和认知能力下降。 目标1：建立翻译听觉和前庭研究的基础设施和专业知识基础。 COBRE资金将使中心内的行政核心能够提供独特的、变革性的 为初级研究人员提供研究环境，将他们的基础科学发现转化为治疗 保护或恢复听力和前庭功能的策略。这将建立一个更广泛的非临床 研究计划。行政核心将协调项目负责人与其 导师和外部咨询委员会。管理核心将开发一个药物发现和 将协调必要的药物筛选分析和铅衍生物生产的交付核心 化合物及其传递到内耳和相关的中枢神经通路以及听觉 前庭技术核心，以验证领先候选耳疗HITS的疗效。 目标2：建立一批受资助的研究人员，领导翻译听觉和前庭 研究。我们将研究听力损失和前庭功能障碍的外周和中枢机制， 并确定药物治疗策略，以保护或恢复听力和前庭功能， 研究人员的研究经费水平。我们还为项目负责人制定了出色的指导计划， 通过作为内部导师的高级调查和生物统计支持来补充他们的专业知识 作为外部调查人员，具有翻译和临床专业知识，作为外部导师。其他指导是 由研究核心工作人员提供，授勋课程和模拟学习部分的建议在审查之前。 对研究进展和所有其他中心活动的评估也是优化中心成功的关键。 该中心还将受益于内布拉斯加州奥马哈蓬勃发展的翻译研究环境。未来 计划要求继续扩大该中心，以包括提交研究新药申请， 与Creighton服务的患者群体合作进行的安全性和有效性研究和临床试验 大学学术医学中心、天主教健康倡议(CHI)健康系统、BTNRH和UNMC。

PROJECT SUMMARY/ABSTRACT Overall Plan for the Translational Hearing Center This Center of Biomedical Research Excellence (COBRE) application is to establish the Translational Hearing Center, administered by centrally-located Creighton University, with Boys Town National Research Hospital (BTNRH) and the University of Nebraska Medical Center (UNMC), as institutional partners. Our overall goal is to build a critical mass of academic translational researchers developing therapeutic interventions to preserve or restore hearing and vestibular function from a wide range of etiologies that cause hearing loss and vestibular deficits. Hearing loss in infants and children results in delayed acquisition of listening and spoken language skills critical for academic achievement and maximal career trajectories of affected individuals. In the aging population, hearing loss and vestibular deficits without appropriate rehabilitation accelerates aging and cognitive decline. Aim 1: Develop the infrastructure and expertise base for translational auditory and vestibular research. COBRE funding will enable an Administrative Core within the Center to provide a unique, transformational research environment for junior investigators to translate their basic science discoveries into therapeutic strategies that preserve or restore hearing and vestibular function. This will establish a broader nonclinical research program. The Administrative Core will coordinate interactions between project leaders with their Mentors, and an External Advisory Committee. The Administrative Core will develop a Drug Discovery and Delivery Core that will coordinate necessary drug screen assays and production of derivatives of lead compounds and their delivery to the inner ear and associated central neural pathways, as well as an Auditory Vestibular Technology Core to validate the efficacy of lead candidate ototherapeutics hits. Aim 2: Build a critical mass of funded investigators leading translational auditory and vestibular research. We will examine both peripheral and central mechanisms of hearing loss and vestibular dysfunction, and identify pharmacotherapeutic strategies preserve or restore hearing and vestibular function, with multiple levels of research funding for investigators. We also have an outstanding Mentoring Plan for project leaders, complementing their expertise with senior investigations as Internal Mentors and biostatistical support, as well as outside investigators with translational and clinical expertise as External Mentors. Additional mentoring is provided by Research Core staff, grantsmanship classes and Mock Study Sections of proposals prior to review. Evaluations of research progress, and all other Center activities, are also key to optimize Center success. The Center will also benefit from the burgeoning translational research environment in Omaha, Nebraska. Future plans call for continued expansion of the Center to include submission of Investigational New Drug applications, safety and efficacy studies and clinical trials in partnership with patient populations served by Creighton University’s academic medical center, Catholic Health Initiatives (CHI) Health system, BTNRH and UNMC.