Administrative and Faculty Development Core

项目摘要 这个新的第一阶段生物医学研究卓越中心(COBRE)提案将开发一个新的 内华达大学雷诺分校(UNR)和UNR医学院内的跨学科研究中心 (UNR Med)，专注于细胞内基本的分子和细胞信号转导机制 心血管系统。这里描述的是核心A，即行政和教师发展核心。核心A将 提供科布雷的行政、财政和科学方面的管理。核心A将由以下人员指导 斯科特·厄利博士，UNR Med药理学教授，首席研究员兼Cobre主任。Dr。 Earley是一位成就卓著的调查员，在NIH R01资金方面有既定的记录，在HIGH- 高质量的期刊，并致力于指导青年科学家。已经为以下方面确定了目标 第一阶段的核心A：1)为中心提供科学的领导和建立行政结构； 2)执行积极的教师发展计划，为学生提供个性化的一对一指导 科布雷的项目负责人。学院发展计划旨在将项目负责人从 由自己的研究项目资助的完全独立的研究科学家的早期职业研究人员身份 拨款(RPG)，如NIH R01或同等标准；3)建立和监测评估里程碑 项目负责人走向科学独立的进展。4)选聘新的项目负责人接替 毕业生；5)促进毕业项目负责人和知名研究人员之间的合作 在中心内开发协作RPG和新的计划项目赠款，以增强长期- 中心的任期可持续性；6)对科布雷实施形成性和总结性评价战略， 项目负责人和研究核心具有特定的里程碑。成功完成这些目标将 在心血管系统建立分子和细胞信号转导的内华达科布雷 一个国际公认的、可持续的多学科研究中心，调查对 健康和疾病期间的心血管功能。

Project Summary This new Phase I Center of Biomedical Research Excellence (COBRE) proposal will develop a new interdisciplinary research Center within the University of Nevada, Reno (UNR), and the UNR School of Medicine (UNR Med) that is focused on fundamental molecular and cellular signal transduction mechanisms in the cardiovascular system. Core A, the Administrative and Faculty Development Core, is described here. Core A will provide management in administrative, fiscal, and scientific aspects of the COBRE. Core A will be directed by Dr. Scott Earley, Professor of Pharmacology at UNR Med, the Principle Investigator and COBRE Director. Dr. Earley is an accomplished investigator with an established track record of NIH R01 funding, publication in high- quality journals, and committed to mentoring young scientists. The following goals have been established for Core A during Phase I: 1) Provide scientific leadership and develop an administrative structure for the Center; 2) Execute an aggressive Faculty Development Plan to provide personalized, one-on-one mentoring for the COBRE’s Project Leaders. The Faculty Development Plan is designed to transition the Project Leaders from early career investigator status to fully independent research scientists funded by their own Research Project Grants (RPGs), such as an NIH R01 or equivalent; 3) Establish and monitor milestones for evaluating the progress of Project Leaders toward scientific independence. 4) Select and recruit new Project Leaders to replace those who graduate; 5) Promote collaborations among graduated Project Leaders and established investigators within the Center to develop collaborative RPGs and new Program Project Grants that will enhance the long- term sustainability of the Center; 6) Implement a formative and summative evaluation strategy for the COBRE, the Project Leaders, and the Research Cores with specific milestones. Successful completion of these goal will establish the Nevada COBRE in Molecular and Cellular Signal Transduction in the Cardiovascular System as an internationally recognized, sustainable multidisciplinary research Center investigating the regulation of cardiovascular function during health and disease.