Core A: Administrative Core

摘要：行政核心 行政核心是规划和协调大学内部所有活动的驱动力 北卡罗来纳州超级基金研究计划(UNC-SRP)。它确保了研究与我们的 首要任务-通过以下途径开发减少IAS和预防疾病的新解决方案 机械论和平移论研究。行政核心的作用是监督和促进 在UNC-SRP内开展工作，以确保对SRP任务的响应。除了履行 根据SRP计划的任务，我们实施符合2018-2023年NIEHS战略计划的研究。 该核心负责监督UNC-SRP的其他九个组成部分。项目1-3使用高度翻译的技术 跨越体外和体内模型，以及人类群体来了解IA诱导的代谢机制 功能障碍/糖尿病。项目4-5提高了预测私人饮水井和 加强清除的创新方法，以减少IAS。在各个项目中，我们使用翻译方法， 横跨体外模型和细胞培养、小鼠模型和人体样本。包括社区在内的四个核心 参与核心、数据管理和分析核心(DMAC)、研究经验和培训 协调核心(RETCC)和化学与分析核心(CAC)。UNC-SRP主任是丽贝卡博士 弗莱是一名生物医学研究员，由副主任费尔南多·帕尔多-曼努埃尔·德博士支持 维莱纳(生物医学研究员)和助理主任迈克尔·艾特肯博士(环境工程师)。弗莱博士， Pardo-Manuel de Villana和Aitken在管理和监督大型银行方面拥有丰富的经验 研究努力，在成功指导方面确立的领导地位，以及相关的补充科学专业知识 对这项提议。他们的跨学科专业知识和经验对实现 行政核心是培育一个激励创新科学的环境，并确保所有北卡罗来纳大学- 战略行动方案项目和核心朝着总体主题“确定减少国际会计准则风险的新方法”而努力。 并从预防疾病的角度阐明了IAS引起的代谢功能障碍的潜在机制。 核心的目标是通过四个目标实现的。首先，我们集成、协调和监控UNC-SRP 跨学科研究活动的重点是减少IAS和预防代谢性疾病/糖尿病。 第二，我们召集咨询小组，就UNC-SRP活动提供关键指导。第三，我们发展 为UNC-SRP利益相关者提供与减少国际会计准则相关的有效研究、翻译和沟通战略 和疾病预防。最后，我们为研究生提供培训和职业发展机会。 和博士后研究员，促进生物医学和环境科学研究的整合 区域。这些目标结合在一起，确保了一个蓬勃发展的研究计划，得到了与 翻译和社区参与合作伙伴，共同关注UNC-SRP以实现我们的使命。 好了！

ABSTRACT: ADMINISTRATIVE CORE The Administrative Core is the driver for the planning and coordination of all activities within the University of North Carolina Superfund Research Program (UNC-SRP). It ensures that the research aligns with our overarching mission-to develop new solutions for iAs reduction and disease prevention through mechanistic and translational research. The role of the Administrative Core is to oversee and facilitate the conduct of work within the UNC-SRP to ensure responsiveness to the SRP mandates. In addition to fulfilling mandates of the SRP program, we implement research that is in line with the 2018-2023 NIEHS Strategic Plan. This Core oversees the nine other components of the UNC-SRP. Projects 1-3 use highly translational techniques spanning in vitro and in vivo models, and human populations to understand mechanisms of iA-induced metabolic dysfunction/diabetes. Projects 4-5 advance the ability to predict iAs contamination in private drinking wells and innovative methods for enhanced removal to reduce iAs. Across Projects, we use a translational approach that spans in vitro models and cell culture, mouse models, and human samples. Four Cores include the Community Engagement Core, Data management and Analysis Core (DMAC), Research Experience and Training Coordination Core (RETCC), and Chemistry and Analytical Core (CAC). The UNC-SRP Director is Dr. Rebecca Fry, a Biomedical Researcher, who is supported in this role by Deputy Director Dr. Fernando Pardo-Manuel de Villena (Biomedical Researcher) and Assistant Director, Dr. Michael Aitken (Environmental Engineer). Drs. Fry, Pardo-Manuel de Villana and Aitken have extensive experience with administration and oversight of large research efforts, established leadership in successful mentoring, and complementary scientific expertise relevant to the proposal. Their interdisciplinary expertise and experience contributes significantly to the goal of the Administrative Core is to foster an environment that stimulates innovative science and ensures that all UNC- SRP Projects and Cores work toward the overarching theme, “Identifying novel methods to reduce iAs exposure and elucidating mechanisms underlying iAs-induced metabolic dysfunction with a vision for disease prevention.” The goal of the Core is achieved through four aims. First, we integrate, coordinate, and monitor UNC-SRP interdisciplinary research activities focused on iAs reduction and metabolic disease/diabetes prevention. Second, we convene advisory groups to provide critical guidance on UNC-SRP activities. Third, we develop effective research translation and communication strategies for UNC-SRP stakeholders related to iAs reduction and disease prevention. Finally, we provide training and career development opportunities for graduate students and post-doctoral fellows that foster integration across the Biomedical and Environmental Science research areas. Combined, these aims ensure a thriving research program bolstered by substantive interaction with translation and community engagement partners, collectively focusing the UNC-SRP to achieve our mission. !