NorthStar Node of the Clinical Trials Network

自2015年加入NIDA国家药物滥用治疗临床试验网络（CTN）以来，北极星 Node为CTN的目标和优先事项做出了重大贡献。北极星节点及其 研究人员已经领导或共同领导了五项CTN方案，作为七项CTN研究的研究中心，共同 担任CTN指导委员会和数据科学工作组主席， 发展委员会，并为几个特殊利益集团作出了贡献。北极星节点的研究 组合包括传统的随机对照试验（CTN-0068），务实的比较有效性 研究（CTN-0098A和CTN-0099），实施科学（CTN-0074、CTN-0098B和CTN-0099）， 基于社区的参与性研究（CTN-0096），数据科学（CTN-0076和CTN-0087），以及健康 服务研究（CTN-0070）。在此应用程序中，北极星节点有七个指导目标 （POLARIS）：1）生成为政策和临床指南提供信息的证据; 2）评估模型 解决共同面临的SUD和医疗和精神状况; 3）使用学习健康的原则 系统进行务实的试验; 4）使用人工智能和其他数据科学方法， 加强可持续城市发展研究和护理; 5）接触研究不足的人群，以确保可持续城市发展研究与以下方面相关： 不同人群; 6）使用实施科学来测试基于证据的SUD实践的整合 进入一般医疗环境;和7）测试SUD治疗的创新策略。潜在研究 这些目的包括1）一种新的甲基苯丙胺使用障碍的治疗干预; 2） 在电子健康记录中开发机器学习算法，以进行目标物质使用筛查 和加强物质使用障碍的诊断; 3）精确/个性化的医学研究， 药代动力学，以更好地定义和完善改善治疗结果的药物给药策略;以及 4)测试协作护理模式，以解决专业成瘾中同时发生的慢性医学疾病 治疗设置。我们的专业知识涵盖多中心临床试验、实施科学、基于社区的 参与式研究，基于EHR的干预措施，机器学习和自然语言处理，以及 卫生服务研究。除了包括城乡一体化保健在内的社区伙伴外， 系统，联邦合格的健康中心服务于代表性不足的少数民族，专业成瘾治疗 项目，儿科和青少年健康诊所，北极星节点带来了附属的研究和 CTN的传播网络，包括CTSA、SIREN、PCORNet、JCOIN、HOPE、网络 成瘾技术转让中心协调办公室，一个学习保健系统培训方案 (K12)，三个NIDA培训计划（T32），以及成瘾医学和成瘾研究金计划 精神病学北极星节点处于很好的位置，可以解决当前和新出现的SUD问题， 该领域的研究，以改善病人的结果和改变卫生系统。

Since joining the NIDA National Drug Abuse Treatment Clinical Trials Network (CTN) in 2015, the NorthStar Node has made significant contributions to the objectives and priorities of the CTN. The NorthStar Node and its investigators have led or co-led five CTN protocols, served as a research site for seven CTN studies, co- chaired the CTN Steering Committee and the Data Science Work Group, served on the Research Development Committee, and contributed to several special interest groups. The NorthStar Node's research portfolio includes traditional randomized controlled trials (CTN-0068), pragmatic comparative effectiveness research (CTN-0098A and CTN-0099), implementation science (CTN-0074, CTN-0098B, and CTN-0099), community-based participatory research (CTN-0096), data science (CTN-0076 and CTN-0087), and health services research (CTN-0070). In this application, the NorthStar Node has seven guiding objectives (POLARIS): 1) generating evidence that informs Policy and clinical guidelines; 2) evaluating models addressing co-Occurring SUD and medical and psychiatric conditions; 3) using principals of a Learning health system to conduct pragmatic trials; 4) using Artificial intelligence and other data sciences approaches to enhance SUD research and care; 5) Reaching understudied populations to ensure SUD research is relevant to diverse populations; 6) using Implementation science to test the integration of evidence-based SUD practices into general medical settings; and 7) testing innovative Strategies for SUD treatment. Potential studies to meet these objectives include 1) a novel therapeutic intervention for methamphetamine use disorder; 2) development of machine learning algorithms in the electronic health record to target substance use screening and enhance substance use disorder diagnoses; 3) precision/personalized medicine studies using population pharmacokinetics to better define and refine medication dosing strategies that improve treatment outcome; and 4) testing collaborative care models to address co-occurring chronic medical illnesses in specialty addiction treatment settings. Our expertise spans multi-site clinical trials, implementation science, community-based participatory research, EHR-based interventions, machine learning and natural language processing, and health services research. In addition to community partners that include urban and rural integrated health systems, federally qualified health centers serving underrepresented minorities, specialty addiction treatment programs, and pediatric and adolescent health clinics, the NorthStar Node brings affiliated research and dissemination networks into the CTN, including CTSA, SIREN, PCORNet, JCOIN, HOPE, the Network Coordinating Office of the Addiction Technology Transfer Centers, a learning health system training program (K12), three NIDA training programs (T32), and fellowship programs in addiction medicine and addiction psychiatry. The NorthStar Node is well situated to address current and emerging SUD issues and advance research in the field in order to improve patient outcome and transform health systems.