CSHL 2023 Brain Barriers Conference

项目摘要 脑屏障 冷泉港实验室 2023年3月28日至4月1日 拟议中的“大脑障碍”会议将于3月28日在冷泉港实验室（CSHL）举行， 2023年4月1日，将聚集中枢神经系统（CNS）屏障领域的领导者，包括BBB 和血-脑脊液屏障，介绍和讨论最新的科学进展，将阐明 健康和疾病的屏障功能。本申请寻求对两年期系列第八次会议的支持， 关于这个话题的CSHL会议。其他非营利组织在实地组织的类似会议， 历史上集中于BBB的更多生理学或药理学方面。相比之下， 科学会议将强调现代，多层次的方法，涵盖细胞，分子， 转录组学、蛋白质组学、遗传学和成像技术来阐明整个生命过程中的CNS屏障生物学。 2023年会议期间将讨论的CNS屏障主题包括：（i）新兴概念和热点主题;（ii） 成像方法;（iii）发展，可塑性和专业化;（iv）3D和类器官CNS屏障模型; (v)健康和疾病中的BBB组学;以及（vi）衰老、衰老和神经变性。近期基本面 CNS屏障的发现，包括关于人BBB中细胞多样性和功能的新知识， 研究屏障生物学技术的新进展以及这些新方法的应用， 了解BBB对神经系统疾病的贡献已经为前所未有的科学研究奠定了基础。 的发现因此，国际研究界的交流对于促进 合作和推动该领域的未来发展。每次会议将由两位顶尖科学家主持 在不同的职业生涯阶段。选定的演讲者将包括2-3名特邀演讲者以及研究生， 博士后研究员和初级教师从提交的摘要中选出。我们非常重视 促进初级调查员，包括由选定的年轻人进行平台介绍的整个会议 研究人员和两个初级教师主持。在会议开始时作一次主旨演讲 将提供该领域的概述和关键背景，以激发整个会议的讨论。 还将举行两次海报展示会，一次关于“妇女和少数群体取得成功的障碍”的小组讨论会 在学术界和工业界：影响和解决办法“，随后举办了关于“如何制定和编写建设性的 和公平的同行审查”。这些会议将为所有与会者的专业成长提供支持 特别是妇女和少数民族在STEM职业中的作用，并刺激所有年轻科学家的科学成长。 三个海报奖（第一名，第二名和第三名）将在最后一节作为最后的简短演讲。的 自2008年成立以来，会议稳步增长，COVID 19期间的虚拟出席率更高 流行病我们预计会议规模适中（200-250名现场参与者和150-250名虚拟参与者 参与者），包括很高比例的学生和博士后研究员。

PROJECT SUMMARY Brain Barriers Cold Spring Harbor Laboratory March 28 - April 1, 2023 The proposed “Brain Barriers” meeting, to be held at the Cold Spring Harbor Laboratory (CSHL) from March 28- April 1, 2023, will assemble leaders in the fields of central nervous system (CNS) barriers, including the BBB and the blood-cerebrospinal fluid barrier, to present and discuss the latest scientific advances that will elucidate barrier function in health and disease. This application seeks support for the eighth meeting of a biennial series of CSHL meetings on this topic. Similar meetings in the field organized by other non-profit organizations have historically focused on more physiological or pharmacological aspects of the BBB. In contrast, this premiere scientific conference will emphasize modern, multi-tiered approaches spanning cellular, molecular, transcriptomic, proteomic, genetic, and imaging technologies to elucidate CNS barriers biology throughout life. CNS barrier topics to be discussed during the 2023 meeting include: (i) Emerging concepts and hot topics; (ii) Imaging approaches; (iii) Development, plasticity, and specialization; (iv) 3D and organoid CNS barrier models; (v) BBB-omics in health and disease; and (vi) Aging, senescence and neurodegeneration. Recent fundamental discoveries in CNS barriers including new knowledge regarding cell diversity and function in the human BBB, new advances in techniques to investigate barrier biology and the application of these new approaches to better understand BBB contribution to neurological diseases have set the stage for an unprecedented scientific discovery. As such, communication within the international research community is essential for fostering collaborations and fueling future advances in the field. Each session will be chaired by a pair of leading scientists at different career stages. Selected speakers will include 2-3 invited speakers as well as graduate students, postdoctoral fellows, and junior faculty selected from submitted abstracts. We have a strong emphasis on promoting junior investigators, including an entire session with platform presentations from selected young investigators and chaired by two junior faculty. One keynote lecture presented at the beginning of the meeting will provide an overview of the field and the critical background to stimulate discussion throughout the meeting. There will also be two poster sessions, one panel discussion on `Barriers to success for women and minorities in academia and industry: impact and solutions' followed by a workshop on “How to frame and write constructive and fair peer-review”. These sessions will provide support for the professional growth of all meeting attendees in particular women and minorities in STEM careers, and stimulate the scientific growth of all young scientists. Three poster prizes (1st, 2nd, and 3rd place) will be presented as late breaking short talks in the final session. The meeting has grown steadily since its inception in 2008 with a much higher virtual attendance during the COVID19 pandemic. We anticipate a meeting of moderate size (200-250 in-person participants and 150-250 virtual participants), including a high proportion of students and postdoctoral fellows.