Training in Neurodegenerative Diseases

随着人口老龄化，阿尔茨海默病(AD)、帕金森病(PD)、肌萎缩侧索硬化症的发病率 硬化症(ALS)和其他相关的神经退行性疾病持续上升，需要成功 翻译研究计划势在必行，以维持健康的老龄化人口并减轻 增加了社会的医疗保健成本。虽然对神经退行性机制的许多了解 在多年的研究中取得了一些成果，但没有多少成果成功地转化为对患者的治疗 呼吁今后从临床角度对这些疾病有更深层次的认识 神经退行性疾病调查员。神经退行性变训练计划(NTP)是为 被选中的学生将在神经变性领域提供严格的博士前科学培训 广泛的临床暴露。NTP的目标是为学员提供必要的基本技能 在神经变性研究方面的杰出事业，以及对挑战和 临床环境下诊断和治疗神经退行性疾病的复杂性。NTP强调 在神经退行性变的基本方面和涉及的疾病机制方面进行严格的博士培训 通过课堂教学，神经变性相关的神经退行性变和临床前景 实验室研究和指导神经退行性疾病临床经验与教育论坛相结合 阐述了临床和转化性神经变性研究中的重要课题。 一批有竞争力的实习生将与最先进的设施中的19名优秀教师相结合，以 研究广泛的神经退行性变相关主题，横跨分子等研究领域 遗传学、蛋白质结构、细胞和分子生物学以及疾病的体外和体内模型。NTP 促进凯斯西储大学各部门和学校之间的合作，特别是 医学院及其在克利夫兰地区的附属机构：克利夫兰大学医院 医学中心(UHCMC)和克利夫兰临床基金会(CCF，包括勒纳研究所)。 所有这些机构都在步行的距离内，这种丰富的培训环境非常享受 活跃的基础科学和临床活动。更新后的课程为 神经退行性研究。广受欢迎的指导神经退行性变的临床经验是 扩展到包括六名知名临床医生，使其能够与患者和护理人员直接互动 靠近CWRU校区的不同临床中心为学员提供在以下方面取得进步的动力 疾病诊断和治疗。最近增加的职业发展和职业充实模块 确保我们的学员做好更好的准备，以实现他们期望的职业目标。总之，NTP培训将 为学员提供出色的神经退行性变相关职业的坚实基础。

As our population ages, the incidence of Alzheimer disease (AD), Parkinson disease (PD), Amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases continues to rise, and the need for successful translational research programs is imperative to maintain a healthy aging population and reduce the burden of increased health care costs on society. While much understanding of neurodegenerative mechanisms have been gained over the years of investigation, not much had been successfully translated into patient treatment which calls for deeper appreciation of these diseases through clinical perspective in the future neurodegeneration investigators. The Neurodegeneration Training Program (NTP) has been designed for selected students to provide rigorous pre-doctoral scientific training in the field of neurodegeneration along with extensive clinical exposure. The goal of the NTP is to provide trainees with the fundamental skills necessary for outstanding careers in neurodegeneration research, together with an appreciation of the challenges and complexity of diagnosing and treating neurodegenerative diseases in the clinical setting. The NTP emphasizes rigorous PHD training in fundamental aspects of neurodegeneration and mechanisms of diseases involving neurodegeneration and clinical perspectives through classroom teaching, neurodegeneration-related laboratory research and mentored neurodegenerative clinical experiences combined with educational forums that address important topics in clinical and translational neurodegeneration research. A competitive pool of trainees will combine with 19 outstanding faculty in state-of –the-art facilities to investigate a wide range of neurodegeneration-related topics spanning research areas such as molecular genetics, protein structure, cell and molecular biology and in vitro and in vivo models of disease. The NTP promotes collaboration between departments and schools at Case Western Reserve University, particularly the School of Medicine, and with its affiliated institutions in the Cleveland area: University Hospitals Cleveland Medical Center (UHCMC), and the Cleveland Clinic Foundation (CCF, including the Lerner Research Institute). All of these institutions are within walking distance of each other and this rich training environment enjoys very active basic science and clinical activities. The updated curriculum provides a solid foundation for neurodegeneration research. The well-received mentored neurodegenerative clinical experience has been expanded to include six renowned clinicians enabling direct interaction with patients and caregivers in several different clinical centers close to CWRU campus providing motivation to the trainees to produce advances in disease diagnosis and therapies. The recently added career development and professional enrichment module ensures better preparedness of our trainees to achieve their desired career goals. Together, NTP training will provide trainees a solid foundation for an outstanding neurodegeneration-related career.