Expansion and modification of animal housing and support spaces to increase production of the NIH U42 supported pigtailed macaque colony at Johns Hopkins University

项目摘要 面对有据可查的生物医学领域非人类灵长类动物的持续短缺 研究和证据表明，它们可能是新冠肺炎的独特模式，也就不足为奇了 对辫尾猕猴的需求依然强劲，而且还在继续攀升。自从美国国立卫生研究院成立以来- 在2006年的支持下，JHU小尾猴群体已经为生物医学提供了313只动物 研究，其中绝大多数是与艾滋病毒/艾滋病有关的。其中有172只(55%) 到国立卫生研究院资助的JHU以外的机构的研究人员那里，我们已经建立了我们的殖民地 作为这一珍贵动物模型的重要国家资源。为了满足日益增长的对 在生物医学研究中，我们制定了一项计划，大幅增加 我们可以在JHU研究农场饲养的动物数量，并进一步完善我们的 对这个繁育群体进行行为管理，以提高生产率。首先，我们建议 在现有12号楼的基础上扩建，大大扩大了动物收容所和 支持空间。这一新建筑将包括动物住所和创新的笼子。 六个后宫的120只额外的动物。此外，还将提供专门的支持服务 空间，包括手术室、放射室、供康复期或休养前使用的弹性空间。 出售动物，以及笼子洗涤区，以及人员空间，如工作人员储物柜 客房配有连通的淋浴、浴室、洗衣房和个人防护用品穿衣/脱衣区。第二，我们 建议在井下安装光缆等网络基础设施，连接 JHU研究农场设施到高速互联网。这个项目将使我们能够充分利用 即将安装的JHU资助的升级到1)安全和2)电子动物健康和 行为记录。如果这项建议成功，我们将更好地服务于NIH资助的研究 在两个关键方面依赖灵长类模型的社区：1)我们将增加 可供研究人员使用的动物和2)我们将评估新的畜牧和行为 设计到新建筑中的管理功能，并与NIH资助的人员分享我们的发现 非人灵长类研究人员和其他国家繁育中心。

Project Summary In the face of well-documented ongoing shortages of nonhuman primates for biomedical research and evidence that they may be a unique model for COVID-19, it is no surprise that the demand for pigtail macaques remains strong and continues to climb. Since the onset of NIH- support in 2006, the JHU pigtail macaque colony has provided 313 animals for biomedical research, the vast majority of which was HIV/AIDS related. With 172 of those animals (55%) going to NIH funded investigators at institutions outside of JHU, we have established our colony as an important national resource of this valuable animal model. To meet the growing need for pigtail macaques in biomedical research, we have developed a plan to significantly increase the number of animals that we can house at the JHU Research Farm and further refine our behavioral management of this breeding colony to improve productivity. First, we propose to construct an addition to the existing Building 12, significantly expanding animal housing and support spaces. This new construction will include animal housing space and innovative caging for 120 additional animals across 6 harems. This addition will also house dedicated support spaces, including an operating room, radiology room, flex holding space for convalescing or pre- sale animals, and a cage washing area, along with personnel spaces such as a staff locker room with connected showers, bathroom, laundry, and PPE donning/doffing area. Second, we propose to install underground fiber optic cable and other network infrastructure to connect the JHU Research Farm facilities to high-speed internet. This project will allow us to fully leverage the soon-to-be-installed JHU-funded upgrades to 1) security and 2) electronic animal health and behavior records. If this proposal is successful, we will better serve the NIH-funded research community that relies on primate models in two key ways: 1) we will increase the number of animals available to researchers and 2) we will evaluate the novel husbandry and behavioral management features designed into the new building and share our findings with NIH-funded nonhuman primate researchers and other national breeding centers.