NIDDK Multidisciplinary Predoctoral Training in Discovery and Translational Research

项目摘要/摘要 这是在发现和翻译研究方面的多学科博士前培训的新应用 糖尿病和代谢疾病、消化疾病和胃肠疾病相关领域的梅奥诊所- 肾脏疾病和高血压(DDK)。最重要的目标是发展一个多样化的 训练有素的生物医学职业科学家，具有成为下一代领导者的经验和技能- DDK研究人员的地位。两位资深的梅奥科学家，他们在 研究生教育和指导将共同指导这个以四个机制为中心的研究项目 1)生物工程和生物物理分析，2)细胞间通讯，3)基因组调节-- 以及(Iv)细胞内信号传递，拥有24名跨学科教员和超过2000万美元的资金。 这一核心的DDK教员提供了强大的基础设施，以及在以下方面培训职业科学家的成功历史 基于发现和转化的生物医学研究。这些实验室提供丰富的指导和培训 为学生个人量身定做的环境，同时促进集体体验 跨多个学科。该计划的具体目标集中在可复制和可复制的基本方面 严格的生物医学研究，符合NIH/NIDDK的优先事项。这些是为了：i)为 科学推理、研究设计、严谨性、定量实验方法和数据集分析， 对结果进行客观解释；ii)促进广泛的多学科理解，并结合关键 独立思考能力，同时具备识别突出生物医学问题和解决问题的能力 采用新方法推动该领域的发展；iii)培养有效的口头和书面沟通技能 多样化的受众；iv)促进生物医学研究中的道德行为和团队技能，以促进合作- 与同事一起进行科学研究，同时促进包容性的工作环境；v)提供 识别并有效地转变为富有成效的基础和临床DDK研究人员的背景。支持- GRAM大力支持梅奥临床基础科学部与NIDDK之间的协同互动- 消化系统疾病、转化性PKD和肠道系统病理生物学的资助中心。学生们-- 学生将积极参加各种方案活动，包括期刊俱乐部、研讨会和作品- 正在进行的系列，职业和专业发展活动，年度务虚会，梅奥研究生院范围 研讨会和海报会议，以及参加国家会议和其他会议。这些活动符合- 与三个相关的DDK博士后项目在梅奥诊所糖尿病和代谢，消化科 疾病和肾脏疾病，同时提供夏季本科生研究的完整连续体 通过博士和博士后培训的经验。完成博士学位证书的要求 符合梅奥研究生院的要求，包括第一作者出版物。该计划借鉴了强大的 超过75名合格的梅奥诊所研究生；我们要求每年支持6名博士前实习生。

PROJECT SUMMARY/ABSTRACT This is a new application for multidisciplinary predoctoral training in discovery and translational research at Mayo Clinic in the inter-related fields of Diabetes and Metabolic Disease, Digestive Diseases and Gastroenter- ology, and Kidney Disease and Hypertension (DDK). The overarching objective is to develop a diverse pool of well-trained biomedical career scientists with the experience and skillsets to become leaders in the next gener- ation of DDK researchers. Two senior and accomplished Mayo scientists with an extensive background in graduate education and mentoring will co-direct this program centered upon four Mechanism-Centric Research Communities in i) Bioengineering and Biophysical Analysis, ii) Cell-to-Cell Communication, iii) Genomic Regu- lation, and iv) Intracellular Signaling, with 24 interdisciplinary faculty members and over $20 million in funding. This core DDK faculty provides a robust infrastructure with a successful history of training career scientists in discovery-based and translational biomedical research. These laboratories offer a rich mentoring and training environment that is uniquely tailored to the individual student while also promoting collective experiences across multiple disciplines. The program's Specific Aims focus on fundamental aspects of reproducible and rigorous biomedical research that align with NIH/NIDDK priorities. These are to: i) Offer a solid foundation in scientific reasoning, research design, rigor, quantitative experimental approaches and analysis of datasets, with objective interpretation of results; ii) Foster broad multidisciplinary understanding combined with critical independent thinking skills, while implementing the ability to identify outstanding biomedical questions and ini- tiate new approaches to advance the field; iii) Develop effective oral and written communication skills across diverse audiences; iv) Promote ethical conduct in biomedical research and team skills that facilitate collabora- tive scientific research alongside colleagues while promoting an inclusive work environment; v) Provide the background to identify and effectively transition into productive basic and clinical DDK investigators. The pro- gram strongly supports synergistic interactions between Mayo Clinic Basic Science Departments and NIDDK- funded Centers in Digestive Disease, Translational PKD, and Pathobiology of the Enteric System. The stu- dents will actively engage in a full array of programmatic activities, including journal clubs, seminar and works- in-progress series, career and professional development events, annual retreat, Mayo Graduate School wide symposium and poster session, along with participation in national meetings and others. These activities syn- ergize with three related DDK postdoctoral programs at Mayo Clinic in Diabetes and Metabolism, Digestive Diseases, and Kidney Disease, while offering a complete continuum from summer undergraduate research experiences through PhD and postdoctoral training. Requirements for completion of the PhD degree conform to Mayo Graduate School requirements, including a first author publication. The program draws from a strong pool of 75+ qualified Mayo Clinic graduate students; we request support for six predoctoral trainees per year.