Integrative Pathways to Health and Illness

摘要-总体 此修订后的申请是为了响应U19资助机会，为中年在美国 （MIDUS）研究。MIDUS的使命是研究健康，广义上，作为一个综合的生物心理社会 这是一个贯穿成年生活数十年的过程。基线研究始于1995年， 成年人，包括双胞胎，年龄在25到74岁之间。这个样本已经被跟踪了20年，沿着，MIDUS 增加了特定城市的非裔美国人样本，最近，一个新招募的国家 示例，称为MIDUS刷新器。采用多项目设计、综合勘察、生物医学、 和神经科学数据已经收集了MIDUS受访者。此外，目前的P01供资 MIDUS促进了第三波调查数据和第二波认知数据的完成。我们寻求 本申请中的资金用于收集每日日记项目，生物标志物项目和 神经科学项目。我们还要求资金启动一个新的基因表达项目，重点是 表达的基因中心的身体的免疫炎症反应，以及保留早期 警告项目，旨在恢复前几波数据收集中的一部分辍学者。这五 项目由一个行政核心、一个生物核心和一个统计核心支持。在所有项目中， 核心，针对上次审查中提出的关切，收集了详细的答复。在 此外，总体计划还记录了围绕MIDUS研究发展起来的巨大势头， 关于数据使用和科学生产力的最新情况，包括产生大量新出版物（88份） 从十个月前第一次提交申请开始 MIDUS填补了NIA支持的纵向研究中的一个独特的利基，鉴于其广泛的年龄范围和 在心理社会学，生物标志物和神经科学评估方面的不寻常的深度，允许关注 社会人口学和社会心理因素 影响健康和疾病的发展概况。一个独特的优势是主题重点是心理社会 力量，这被用来解释许多成年人面对各种各样的 逆境MIDUS还包括一个全国性的双胞胎样本，从而提供了独特的晋升机会。 了解遗传和环境因素在理解健康或不健康衰老中的相互作用。 重要的是，MIDUS已经引起了科学界的注意：它是最常见的 国家老龄化计算机数据档案馆（NACDA）的研究。近700篇文章 其中许多在建立社会人口、心理社会 和神经生物学因素来解释晚年发病率和死亡率的不同途径。

ABSTRACT - Overall This revised application is in response to the U19 funding opportunity for the Midlife in the United States (MIDUS) study. The mission of MIDUS is to study health, broadly defined, as an integrated biopsychosocial process that unfolds across the decades of adult life. The baseline study was begun in 1995 with over 7,000 adults, including twins, aged 25 to 74. This sample has been followed for 20 years, and along the way, MIDUS was augmented with city-specific sample of African Americans, and more recently, a newly recruited national sample, known as the MIDUS Refresher. Using a multi-project design, comprehensive survey, biomedical, and neuroscience data have been collected on MIDUS respondents. In addition, current P01 funding of MIDUS has facilitated the completion of a 3rd wave of survey data and 2nd wave of cognitive data. We seek funds in this application to collect longitudinal data for the Daily Diary Project, the Biomarker Project, and the Neuroscience Project. We also request funds to initiate a new Gene Expression Project focused on the expression of genes central to the body's immune-inflammatory response as well as a Retention-Early Warning Project, designed to reinstate a portion of drop-outs from prior waves of data collection. These five projects are supported by an Administrative Core, a Bio Core, and a Statistics Core. Across all projects and cores, detailed responses have been assembled in response to concerns raised in the prior review. In addition, the Overall Plan documents the enormous momentum that has grown up around the MIDUS study via updates on data usage and scientific productivity, including the high volume of new publications (88) generated just since this application was first submitted ten months ago. MIDUS fills a unique niche among NIA-supported longitudinal studies, given its wide age expanse and its unusual depth in psychosocial, biomarker, and neuroscience assessments, which permit a focus on the neurobiological mechanisms and pathways through which sociodemographic and psychosocial factors influence unfolding profiles of health and illness. A unique strength is the thematic focus on psychosocial strengths, which are being used to explicate profiles of resilience in many adults confronted with varieties of adversity. MIDUS also includes a national twin sample, thus offering unique opportunities to advance knowledge of the interplay of genetic and environmental factors in understanding healthy or unhealthy aging. Importantly, MIDUS has captured the attention of the scientific community: it is the most frequently downloaded study at the National Archive of Computerized Data on Aging (NACDA). Nearly 700 publications have been generated, many breaking new ground in forging linkages among sociodemographic, psychosocial, and neurobiological factors to account for differing pathways to later life morbidity and mortality.