Transplant Surgery Scientist Training Program

项目摘要/摘要 移植有望扭转数百万患有终末期心脏病的美国人的临床进程。 肝病分期。然而，有几个问题限制了更广泛的肝移植和更好的结果 包括对肝病发病机制的不完全理解，对更好治疗方法的需要和 评估临床结果、改善捐赠者的可获得性和获得医疗服务。因此，长久以来- 移植外科科学家培训计划(TSSTP)的学期目标是培养和支持多个 与肝移植相关的学科、跨部门研究将改善终末期肝移植患者的预后。 肝脏疾病分期。我们将在许多学科中利用生命科学的科学进步， 目标是改善移植前和移植后肝脏患者的健康，与 NIDDK。TSSTP将培训下一代外科医生、肝病专家和博士生 肝移植相关领域的范围。该计划的目标是教育受训者有关自然的知识 消除阻碍改善途径、降低并发症和改善肝脏转归的现有障碍 并对TSSTP学员进行培训，使其深入了解最先进的工具、方法和 可以用来克服这些障碍的科学方法。我们将应用团队科学方法， 利用模块化方法进行跨学科专家的移植研究(矩阵)模型，该模型 倡导相互依存、多学科交叉的研究理念。矩阵培训模式建立在 综合移植中心(CTC)内的跨学科团队科学结构，并提供1)基本的 西北大学移植协作组内的转化型科研轨道 免疫/肝生物学和生物医学工程研究(NUCTRIBE)，以及2)结果科学轨道 在西北大学移植结果研究协作组(NUTORC)。实习生将 受益于一个定制的矩阵，该矩阵将整合来自NUCTRIBE和 NUTORC(3-5名TSSTP导师)。每个项目都必须与肝移植或肝病相关，而且 加强我们改善病人护理的长期目标。为了成功实现这些目标，我们力求： 1)提供跨学科的培训和指导，将临床医生和科学家聚集在一起， 最先进的研究方法专家；2)维持一个提高质量和多样性的管理结构 人才库和学员；3)进行严谨和负责任的研究；4)优化导师和学员 通过持续的评估过程进行反馈，以增强计划实现其目标和 目标；以及5)提供培训机会，包括许多讲座和研讨会 和NUTORC在其与临床肝移植的交叉点。这是一个综合性的、多学科的 方法将使我们能够加强与肝脏移植相关的研究，并培训下一代 医生和科学家，这样我们才能改善病人的护理。

PROJECT SUMMARY/ABSTRACT Transplantation holds the promise of reversing the clinical course for millions of Americans afflicted with end- stage liver disease. However, several issues limit broader access to liver transplantation and better outcomes including an incomplete understanding of liver disease pathogenesis, the need for better therapies and assessment of clinical outcomes, improved donor availability and access to medical care. Therefore, the long- term objective of the Transplant Surgery Scientist Training Program (TSSTP) is to foster and support multi- disciplinary, inter-departmental liver transplant-related research that will improve outcomes for patients with end- stage liver diseases. We will leverage scientific advances in the life sciences across many academic disciplines, with a goal of improving the health of pre- and post-transplantation liver patients, consistent with the mission of NIDDK. The TSSTP will train the next generation of surgeons, hepatologists and PhD investigators in a broad range of liver transplantation-related fields. The goals of the program are to educate trainees about the nature of existing barriers that hinder improved access, lower complications, and improve outcomes in liver transplantation; and to train TSSTP trainees with a deep knowledge of state-of-the art tools, methodologies, and scientific approaches that may be used to overcome these barriers. We will apply a team science approach that utilizes the Modular Approach to Transplant Research by Inter-disciplinary eXperts (MATRIX) model which promotes the concept of inter-dependent, multi-disciplinary research. The MATRIX training model builds on the interdisciplinary team science structure within the Comprehensive Transplant Center (CTC) and offers 1) a basic and translational scientific research track within the Northwestern University Collaborative for Transplant Research in Immuno/Hepatobiology and Biomedical Engineering (NUCTRIBE), and 2) outcomes science track within the Northwestern University Transplant Outcomes Research Collaborative (NUTORC). Trainees will benefit from a customized MATRIX that will incorporate multi-disciplinary mentoring from both NUCTRIBE and NUTORC (3-5 TSSTP mentors). Each project must have a link to liver transplantation or hepatology, and enhancing our long-term goal of improving patient care. In order to successfully reach these goals, we seek to: 1) provide inter-disciplinary training and mentorship that brings together clinicians and scientists with state-of- the-art research methodologists; 2) sustain an administrative structure that enhances quality and diversity of the candidate pool and trainees; 3) conduct rigorous and responsible research; 4) optimize mentor and trainee feedback with an ongoing evaluation process to enhance the ability of the program to meet its goals and objectives; and 5) provide training opportunities, including many lectures and seminars, that span NUCTRIBE and NUTORC at their intersection with clinical liver transplantation. This comprehensive, multi-disciplinary approach will allow us to enhance our liver transplantation-related research and train the next generation on physicians and scientists so that we can improve patient care.