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Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers

Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers
高龄父亲:高龄父亲后代的行为、神经解剖学和基因组相关性
批准号:
nhmrc : 569528
负责人:
A/Pr Thomas Burne
金额:
$33.44万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2012-12-31

项目摘要

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中文摘要
翻译
年长父亲的后代患自闭症和精神分裂症等疾病的风险增加。这被认为是由于发育中的精子发生突变。我们的研究小组在小鼠模型中发现,年长父亲的后代在大脑形状和行为上都有变化,这与自闭症的一些发现相似。在这项资助中,我们将完善这种动物模型,并探索先进的父亲年龄的大脑,行为和遗传相关性。
英文摘要
The offspring of older fathers have an increased risk of developing disorders such as autism and schizophrenia. This is thought to be due to mutations in the developing sperm. Our group has shown in a mouse model that the offspring of older fathers have changes in brain shape and in behaviour, similar to some findings in autism. In this grant we will refine this animal model and explore the brain, behavioural and genetic correlates of advanced paternal age.
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会议论文
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  • 项目类别:
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    nhmrc : GNT1099709
  • 项目类别:
    Project Grants
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  • 依托单位:
Delayed radial glial maturation linked to NFI deficiency as an underlying cause of cortical defects in humans and mice
  • 批准号:
    nhmrc : 1100443
  • 项目类别:
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  • 资助金额:
    $54.93万
  • 财政年份:
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海外基金