Animal Medicine COVID Support

翻译研究计划(TRP)在VRC有三个主要职能：1)为VRC进行的所有活体研究提供集中支持和服务；2)开展合作研究和动物模型开发；3)运营完全认可的实验动物设施。 TRP通过管理所有临床前安全和监管问题，确保符合所有机构、地方、州和联邦指南的明智和人道的动物使用，提供全方位的监督和方案援助，以支持教学、培训和活体研究。它是VRC在选择合适的动物模型或建立研究疾病和疫苗效果的新模型方面提供咨询、合作和专业协助的主要资源。 TRP致力于独立和合作的研究项目，涉及流感、甲型病毒等新出现的传染病和其他以生物防御为重点的疾病的动物模型和临床前产品开发。转化性研究是通过积极监测和监督有效性、安全性和毒理学研究，将疫苗产品从临床前阶段推进到人类临床试验，为产品开发的监管监督做准备。TRP还研究新的疫苗交付方法，以提高效率、疫苗效力和安全性。 TRP是一家完全认可的AAALAC内部动物设施，遵守所有联邦法规。该设施为啮齿动物提供优质的畜牧服务、兽医护理和设施管理支持。该设施为供应商和群体生产的动物提供预防性医疗护理、常规监测和质量保证，如有必要，还可以建立和维持自己的老鼠繁育群体。设施工作人员执行各种技术服务，包括非肠道注射或口服动物保护和使用委员会(ACUC)批准的实验材料；血液、组织和血清收集；外科操作；动物识别程序；电穿孔程序；麻醉/止痛给药；以及根据需要进行其他程序。兽医护理单位还为那些希望自己执行这些程序的人提供培训。对于在其他设施进行的VRC研究，TRP建立了调查人员与这些设施之间的合同协议和协调。在内部设施和合同设施内，TRP确保高质量的研究符合法规指南，并遵守良好的实验室实践(GLP)和必要的生物安全水平要求。

The Translational Research Program (TRP) serves three major functions at the VRC: 1) provides centralized support and service for all in vivo research conducted at the VRC, 2) conducts collaborative research and animal model development, and 3) operates a fully accredited lab animal facility. TRP provides all aspects of oversight and programmatic assistance to support teaching, training, and in vivo research by managing all preclinical safety and regulatory issues, ensuring judicious and humane use of animals in compliance with all institutional, local, state, and federal guidelines. It is the VRC primary resource for consultation, collaboration, and professional assistance in selecting appropriate animal models or establishing novel models to study disease and vaccine effects. TRP pursues independent and collaborative research projects related to animal model and preclinical product development for influenza, emerging infectious diseases such as alphaviruses, and other biodefense-focused diseases. Translational research is conducted to advance vaccine products from preclinical stages toward human clinical trials by actively monitoring and overseeing efficacy, safety, and toxicology studies in preparation for regulatory oversight of product development. TRP also investigates novel vaccine delivery methods to enhance efficiency, vaccine efficacy, and safety. TRP serves as a fully accredited AAALAC in-house animal facility, adhering to all federal regulations. The facility provides quality animal husbandry services, veterinary care, and facility management support for rodents. The facility offers preventive medical care, routine surveillance, and quality assurance for vendor- and colony-produced animals and may also establish and maintain its own mouse breeding colonies if necessary. A variety of technical services are performed by facility staff, including parenteral injections or oral administration of Animal Care and Use Committee (ACUC)-approved experimental materials; blood, tissue, and serum collection; surgical manipulations; animal identification procedures; electroporation procedures; anesthesia/analgesic administration; and other procedures as needed. The veterinary care unit also offers training for those who wish to perform these procedures themselves. For VRC studies conducted at other facilities, TRP establishes contractual agreements and coordination between investigators and these facilities. Within the in-house facility and contracted facilities, TRP ensures high-quality research in accordance with regulatory guidelines and compliance with good laboratory practices (GLP) and biosafety level requirements as essential.