Integrative Pharmacological Sciences Training Program (IPSTP)

项目摘要/摘要 密歇根州立大学综合药理学培训项目(IPSTP)设计 支持二年级和三年级的博士生进行药理学的论文研究项目 科学。实习生和培训教师来自7个系博士项目(生物化学和 分子生物学、化学、化学工程与材料科学、微生物学与分子遗传学 神经科学、药理学和毒理学以及生理学)。IPSTP将为学生提供增强的 在体内药理、药物发现和大数据领域进行培训。IPSTP的研究专长 培训教师分为三个相互重叠的主题：1)分子机制的交集 疾病与新的治疗设计；2)内分泌和代谢紊乱与癌症和 心血管过程；3)系统生物学和生物信息学在理解药物方面的应用 机制和疾病。需要资金支持8名学生(每年4名学生进入该项目)。 NeuBig博士和Dorrance博士将担任联席主任，Leinninger博士和Luyendyk博士将担任助理 董事们。董事将由一个执行委员会协助，执行委员会由来自 项目和2名学生代表。该方案还由一个外部咨询委员会 来自药理学博士项目和制药行业的专家。有8个核心要素 培训计划：1)一个导致博士论文的研究项目和对知识的贡献 药理科学；2)为期三周的药物发现、体内药理学、 和计算化学/大数据；3)药理学和生物统计学的三门课程；4)培训 科学严谨性和重复性5)专业发展论坛；6)参加年度计划 休养生息；7)月刊俱乐部和粉笔谈话计划，8)个性化发展计划计划。 学生将在他们的直接T32支持期间和T32期间参加最后四个要素 在随后的几年里，直到毕业。学员还被要求参加负责任的研究行为 研究生院提供的(RCR)系列讲习班和具体方案的RCR活动。补充 学员可参加的活动包括：1)教学机会；2)参加国立卫生研究院资助的密歇根州立大学BEST 计划，以及3)非学术职业的地区性实地考察。IPSTP已经开发出一种 全面计划招收高素质学生，包括代表性不足的少数族裔学生。我们有 还为课程和学生评估制定了全面的计划。还需要进行导师培训 对于所有IPSTP项目，将对教师和学生接受的指导质量进行评估。这个 IPSTP将为学员提供优秀的研究和专业培训，并为他们的研究做好准备。 在学术界、工业界和政府的职业生涯。

Project Summary / Abstract The Integrative Pharmacological Sciences Training Program (IPSTP) at Michigan State University is designed to support 2nd and 3rd year Ph.D. students pursuing dissertation research projects in the pharmacological sciences. Trainees and training faculty are drawn from 7 departmental Ph.D. programs (Biochemistry & Molecular Biology, Chemistry, Chemical Engineering and Materials Science, Microbiology & Molecular Genetics, Neuroscience, Pharmacology & Toxicology, and Physiology). The IPSTP will provide students with enhanced training in the fields of in vivo pharmacology, drug discovery, and big data. The research expertise of IPSTP training faculty is clustered into three overlapping themes: 1) the intersection of molecular mechanisms of disease with novel therapeutic design; 2) integration of endocrine and metabolic derangements with cancer and cardiovascular processes; and, 3) application of systems biology and bioinformatics to understand drug mechanisms and disease. Funds are requested to support 8 students (4 students entering the program per year). Dr. Neubig and Dr. Dorrance will serve as Co-Directors, Dr. Leinninger and Dr. Luyendyk will serve as Associate Directors. The Directors will be assisted by an Executive Committee composed of representatives from the programs and 2 student representatives. The program is also guided by an External Advisory Committee of experts from Pharmacology Ph.D. programs and the pharmaceutical industry. There are 8 core elements to the training plan: 1) a research project that leads to a Ph.D. dissertation and a contribution to knowledge in the pharmacological sciences; 2) three week-long intensive boot camps in drug discovery, in vivo pharmacology, and computational chemistry/big data; 3) a three-course curriculum in pharmacology and biostatistics, 4) training in scientific rigor and reproducibility 5) a Professional Development Forum; 6) participation in an annual program retreat; 7) a monthly journal club and chalk talk program, and 8) an individualized development plan program. Students will be expected to participate in the last four elements both during their direct T32 support period and for subsequent years until graduation. Trainees are also required to attend the Responsible Conduct of Research (RCR) workshop series provided by the Graduate School and program-specific RCR activities. Supplemental activities available to trainees include: 1) teaching opportunities; 2) participation in the NIH-funded MSU BEST program, and 3) field-trips to regional sites for non-academic careers. The IPSTP has developed a comprehensive plan to recruit highly qualified students including under-represented minority students. We have also developed comprehensive plans for program and student evaluation. Mentor training will also be required for all IPSTP program faculty and the quality of the mentoring received by the students will be assessed. The IPSTP will provide trainees with excellent research and professional training and will prepare them for research careers in academia, industry and government.