Cell Signaling of Host Defense

国立环境卫生科学研究所呼吸生物学实验室校内研究部宿主防御小组，由Michael B领导。Fessler，MD现在进入自成立以来在NIEHS的第三年。我们已经将实验室的工作人员增加到6名。成就包括原始出版物（Smoak K等人，Journal of Immunology 2008;180（5）：3305-12），其定义了核受体肝X受体在调节肺先天免疫中的新作用，3篇综述文章已发表或在出版中，关于肝X受体在肺部炎症中的已发表和Pubmed索引的会议摘要（Madenspacher JH等人，Proc Am Thorac Soc.2008 Apr;5（3）：366），以及关于巨噬细胞筏的蛋白质组学分析的原始手稿，其已经重新提交，并进行了微小的修订（Molecular & Cellular Proteomics）。 其他成就包括2009年FARE研究员Suraj Dhungana的摘要奖，由NIEHS脂质筏生物学研讨会的Fessler博士组织和主持，由NIEHS杰出讲师Fessler博士于2008年5月主持（Kai Simons），任命Fessler博士为美国胸科学会（ATS）RCMB大会成员，Fessler博士举办了5次区域研究研讨会，Fessler博士在2008年ATS国际会议上主持了基因组学/蛋白质组学海报会议，Fessler博士在戈登脂蛋白代谢研究会议上展示了海报。 此外，本实验室还开展了5个研究项目：1）载脂蛋白A-I作为一种新型天然免疫刺激物的特性研究; 2）病毒融合蛋白作为一种新型天然免疫刺激物的特性研究; 3）发现LPS诱导巨噬细胞脂筏募集的新型信号蛋白; 4）在吸入LPS的鼠模型和人哮喘中，确定血脂异常对肺先天免疫的调节作用;和5）研究胆固醇运输调节剂在肺先天免疫应答中的作用。 目前，2份新的原稿正在最后编写中，即将提交。

The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its third year at the NIEHS since inception. We have increased our staffing to 6 active laboratory members. Accomplishments include an original publication (Smoak K et al., Journal of Immunology 2008;180(5):3305-12) that defines a novel role for the nuclear receptor Liver X Receptor in modulation of pulmonary innate immunity, 3 review articles published or in press, a published and Pubmed-indexed meeting abstract on Liver X Receptor in lung inflammation (Madenspacher JH et al., Proc Am Thorac Soc. 2008 Apr;5(3):366), and an original manuscript on proteomic analysis of macrophage rafts that has been resubmitted with minor revisions (Molecular & Cellular Proteomics). Additional accomplishments include a 2009 FARE abstract award for Research Fellow Suraj Dhungana, organization and chairing by Dr. Fessler of an NIEHS Symposium on Lipid Raft Biology, hosting by Dr. Fessler of the NIEHS Distinguished Lecturer for May 2008 (Kai Simons), appointing of Dr. Fessler to the American Thoracic Society (ATS) RCMB Assembly, delivery of 5 regional research seminars by Dr. Fessler, chairing by Dr. Fessler of a genomics/proteomics poster session at the 2008 ATS International Conference, and presentation by Dr. Fessler of a poster at the Gordon Research Conference on Lipoprotein Metabolism. In addition, substantial data has been collected on 5 active research projects in the laboratory: 1) characterization of apoplipoprotein A-I as a novel stimulus of innate immunity; 2) characterization of viral fusion proteins as novel innate immune stimuli; 3) proteomic discovery of novel signaling proteins recruited to macrophage lipid rafts in response to LPS; 4) identification of a modulatory role of dyslipidemia upon pulmonary innate immunity in a murine model of inhaled LPS and in human asthma; and 5) investigation of a role for cholesterol trafficking regulators in pulmonary innate immune responses. Presently, 2 new original manuscripts are under final preparation and will be submitted imminently.