Health Outcomes in Blood Donors and Recipients

描述（由申请人提供）：Murphy博士是一位声誉良好，资金充足且富有成效的研究人员，他在第一个资助期内有效地利用了K24机制，以利用他参与患者导向研究（POR），并投入大量额外的时间进行培训和指导。他成功地指导了研究生、研究员和初级教师在POR的职业生涯。更新颖的是，但仍然完全在K24奖的意图范围内，他在发展中国家为输血医学博士和博士建立了一个充满活力的POR培训新项目，这将导致新一代研究人员致力于在全球范围内提高输血的安全性和可用性。最后，在研究和培训活动与对行政职责的剩余承诺之间仍然存在对时间和资助薪金的竞争需求。虽然中长期师徒关系已经取得了成功，但国际项目还很年轻，申请人希望有更多的时间让几名有前途的学员从短期课程过渡到中长期师徒关系。要求再提供五年的资金，以便成立一个国际输血安全贫血症培训卓越中心：继续并扩大他的高质量贫血症方案，重点研究输血传播病毒和遗传流行病学的健康后果。在加州大学旧金山分校CTSI、加州大学伯克利分校公共卫生学院和加州大学旧金山分校新的路线图K12硕士和博士项目的支持下，继续并增加中长期指导。与UCSF全球健康研究所和NIH福格蒂国际中心合作，扩大并获得独立的国际培训活动资金。进一步加强自己的研究团队，促进初级教师的独立性，并联合（UCSF和BSRI）招募一名遗传流行病学家，以帮助实验室扩展到这一新的研究领域。相关性（见说明）：这项研究培训资助将支持申请人进行以患者为导向的研究，并培训年轻的内科科学家进行这类研究。该计划将在美国培养研究生、博士后和初级教员，并在发展中国家培养输血医生。

DESCRIPTION (provided by applicant): Dr. Murphy is a well-established, well-funded and productive researcher who has productively utilized the K24 mechanism during the first funding penod to leverage his participation in patient onented research (POR) and to devote substantial additional time to training and mentoring. He has been successful in traditional mentoring of graduate students, fellows and junior faculty towards their own career in POR. More novel, but still fully within the scope of the K24 award's intent, he has instituted a dynamic new program in POR training for transfusion medicine MD's and PhD's in developing countries that will lead to a new generation of researchers devoted to improving the safety and availability of blood transfusion on a woridwide basis. Finally, there are still competing demands for time and funded salary between research and training activities and remaining commitments to administrative duties. Although medium-long term mentorship has been successful, the international program is still young and the applicant would like more time for several promising trainees from the short course to transition to medium to long term mentorship. An additional five years of funding is requested to enable the formation of a Center of Excellence in POR training in international transfusion safety: Continue and expand his program of high quality POR, with a research concentration on the health outcomes of transfusion transmitted viruses and genetic epidemiology. Continue and increase medium- and long-term mentorship under the umbrella of the UCSF CTSI, UC Berkeley School of Public Health and the new roadmap K12 Masters and Ph.D. programs at UCSF. Expand and obtain independent funding for international training activities, in collaboration with the UCSF Institute for Global Health, and NIH Fogarty International Center training grants Further strengthen his own research team, promoting the independence of junior faculty and a joint (UCSF and BSRI) recruitment of a genetic epidemiologist to aid the laboratory's expansion into this new area of research. RELEVANCE (See instructions): This research training grant will support the applicant in his efforts to perform patient oriented research, and to train younger physician scientists to do this kind of research. The proposal will train graduate students, postdoctoral fellows and junior faculty in the USA and transfusion doctors in developing countries.