Marietta Community Actively Researching Exposure Study

项目摘要 锰（Mn）是一种必需元素，但过量时具有神经毒性。尽管 婴儿和幼儿可能比成人有更大的锰神经毒性风险， 很少有研究评估慢性锰暴露对儿童的影响， 发展俄亥俄州的玛丽埃塔是阿巴拉契亚山区的一个乡村社区， 50多年来，它是美国和加拿大唯一的金属精炼厂。作为回应，社区 清洁空气的邻居（NCA）辛辛那提大学（UC）一直在 NCA要求帮助他们了解他们的接触和相关的健康影响， 如有对于这个项目，玛丽埃塔社区积极研究暴露研究 （CARES），社区已经确定了研究议程，确定了研究 问题、目标、具体目标和确定可利用的资源 社区进行研究。社区成员将参与所有 研究项目的各个方面，包括环境采样，神经行为 评估、项目协调和收集生物标本。主 本申请的目的是检查锰暴露的生物指标， 了解慢性锰暴露对儿童的影响。UC将 提供环境卫生研究方面的培训、监督和专门知识， 以下假设：在幼儿期暴露于锰显著 与7-8岁高暴露儿童的神经发育缺陷相关 与年龄匹配的低/未暴露组相比。为了验证这一假设， 将实现以下社区驱动的具体目标。具体目标1：评估 环境锰暴露在高锰暴露社区，玛丽埃塔，OH和 俄亥俄州剑桥低锰暴露社区。具体目标2：评估比较 高锰暴露对儿童神经行为的影响 社区，玛丽埃塔，OH和低锰暴露社区，剑桥，俄亥俄州。具体 目的3：评价暴露于锰的儿童神经运动效应的比较 暴露社区，玛丽埃塔，OH和低锰暴露社区，剑桥， 俄亥俄州。鉴于儿童对有毒物质接触的独特敏感性， 有机会研究锰暴露在一个长期暴露的社区，我们预计， 该项目将对当地和国家与锰有关的公共卫生政策产生重大影响 exposure.项目叙述 暴露于锰（Mn）可导致神经缺陷，这里是 全球以MMT形式暴露于Mn的巨大潜力，MMT是一种抗爆剂， 取代汽油中的铅。玛丽埃塔社区积极研究暴露研究 （CARES）是一项以社区为基础的研究，旨在探讨长期服用 儿童锰暴露。

Project Summary Manganese (Mn) is an essential element, yet is neurotoxic in excess. Despite the fact that infants and young children may be at greater risk for Mn neurotoxicity than adults, very few studies have evaluated the effect of chronic Mn exposure on child development. Marietta, Ohio, a rural Appalachian community, has been home to the only metal refinery in the US and Canada for over 50 years. In response, the community formed Neighbors for Clean Air (NCA). The University of Cincinnati (UC) has been asked by NCA to assist them in understanding their exposure and related health effects, if any. For this project, Marietta Community Actively Researching Exposure Study (CARES), the community has defined the research agenda, determining the research questions, objectives, specific aims and identifying resources available within the community to conduct the research. Members of the community will be engaged in all facets of the research project, including environmental sampling, neurobehavioral assessment, project coordination, and collection of biological specimens. The primary objectives of this application are to examine biological indicators of Mn exposure in children and understand the effects of chronic manganese exposure in children. UC will provide training, oversight and expertise in environmental health research, to address the following hypothesis: Exposure to Mn during early childhood is significantly associated with neurodevelopmental deficits in high exposed children ages 7-8 years compared to an age matched low/unexposed group. In order to test the hypothesis, the following community-driven specific aims will be accomplished. Specific Aim 1: Assess environmental Mn exposure within a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 2: Evaluate comparisons of the neurobehavioral effects in children exposed to Mn in a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 3: Evaluate comparisons of the neuromotor effects in children exposed to Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Given the unique susceptibility of children to toxicant exposure and the opportunity to study Mn exposure in a chronically exposed community, we anticipate this project to significantly impact local and national public health policy related to Mn exposure. Project Narrative Exposure to manganese (Mn) can result in neurological deficiencies, and here is great potential for global exposure to Mn in the form of MMT, an anti-knock agent to replace lead in gasoline. The Marietta Community Actively Researching Exposure Study (CARES) is a community-based study designed to explore the health effects of long term Mn exposure in children.