Molecular and Cellular Basis for Digestive Diseases

总体描述(由申请人提供)： 这项申请是为了继续支持范德比尔特消化疾病研究中心(VDDRC)，该中心专注于消化疾病的分子和细胞机制研究。我们认为，对这些过程的基本了解将为制定有针对性的预防和治疗提供合理的基础。VDDRC是多学科的，包括10个不同学术部门的教员，有77名调查人员(50名正式成员和27名准成员)。VDDRC的目标与范德比尔特大学的目标一致：1)以综合、合作和多学科的方式促进与消化疾病相关的研究；2)提高VDDRC成员的基础研究能力；3)吸引不参与消化疾病相关研究的研究人员从事这些研究；4)制定和实施消化系统疾病相关研究的培训、建立和留住年轻研究人员的计划；以及5)促进将基础研究成果转化为改进预防和/或临床护理。成员的研究兴趣分为四大领域：1)生长、增殖和凋亡，2)上皮完整性，3)胃肠发育和功能，4)胃肠生理、肥胖和新陈代谢。VDDRC包括五个核心研究实验室，以支持成员：1)微阵列核心，2)细胞和动物建模核心，3)细胞成像核心，4)生物分析(质谱学)和蛋白质组学核心，以及5)流式细胞术核心。这些都被整合到我们的中心，为致力于消化疾病相关研究的研究人员提供最新的技术进步，并在实验设计和结果解释方面提供帮助。VDDRC支持一项试点/可行性计划，其中包括一个由大学支持的翻译项目，以及一个青年研究人员奖励计划，以促进初学者和经验丰富的研究人员参与与消化系统疾病相关的研究。行政核心还包括生物统计和浓缩方案，并监督VDDRC的财务管理和运作。VDDRC研究计划通过研究中心提供的技术，旨在改善人类消化系统疾病的预防、管理、结果或治疗。

DESCRIPTION, OVERALL (provided by applicant): This application is for continued support of the Vanderbilt Digestive Disease Research Center (VDDRC) focused on the study of the molecular and cellular mechanisms responsible for digestive diseases. We believe that a fundamental understanding of these processes will provide a rational basis for development of targeted prevention and therapies. The VDDRC is multidisciplinary, including faculty in 10 different academic departments with 77 investigators (50 full members and 27 associate members). The Aims of the VDDRC are aligned with the goals of Vanderbilt University: 1) to promote digestive diseases-related research in an integrative, collaborative and multidisciplinary manner; 2) to enhance the basic research capabilities of VDDRC Members; 3) to attract investigators not involved in digestive diseases-related research to pursue these lines of investigation; 4) to develop and implement programs for training, establishment, and retention of young investigators in digestive disease-related research; and 5) to facilitate the transfer of basic research findings to improvements in prevention and/or clinical care. Investigative interests of the members fall into four broad areas of study: 1) growth, proliferation, and apoptosis, 2) epithelial integrity, 3) gastrointestinal development and function, and 4) gastrointestinal physiology, obesity, and metabolism. The VDDRC contains five core research laboratories to support the members: 1) the Microarray Core, 2) the Cellular and Animal Modeling Core, 3) the Cell Imaging Core, 4) the Bioanalytical (Mass Spectrometry) and Proteomics Core, and 5) the Flow Cytometry Core. These are integrated into our Center to provide investigators working on digestive disease-related research with the latest advances in technology and aid in experimental design and interpretation of results. The VDDRC supports a Pilot/Feasibility Program including a university-supported translational project, and a Young Investigator Award Program to foster participation of beginning and seasoned investigators in research related to digestive diseases. The Administrative Core also contains Biostatistical and Enrichment Programs and oversees the financial management and operation of the VDDRC. The VDDRC Research Programs through technologies provided by the Research Cores are designed to improve prevention, management, outcomes or treatment of human digestive diseases.