HIV Research Program in Thailand and Cambodia

描述（由申请人提供）： 执行一项协调的方案，研究在资源有限（泰国）和资源有限（柬埔寨）的情况下使用抗逆转录病毒疗法和减少危险行为的问题。该计划的主要主题是在发展中国家适当和具有成本效益地使用抗逆转录病毒疗法。 具体目标 1.评估廉价和后勤简单的抗逆转录病毒治疗监测策略 2.在资源有限的情况下，比较立即与延迟治疗艾滋病毒感染儿童的策略 3.评估在管理艾滋病毒/结核病合并感染中开始ARV治疗的最佳时机 4.研究行为干预对减少接受抗逆转录病毒治疗的患者的危险行为和HIV传播的作用 5.使用家庭单位招聘战略将项目联系起来 6.加强泰国和柬埔寨的临床和预防研究能力 7.指导泰国和柬埔寨的临床和公共卫生政策 方法 拟议的CIPRA项目将调查治疗和行为干预措施，为泰国、柬埔寨和该地区其他国家的公共卫生政策提供信息。将使用的研究方法是随机临床试验和观察性队列。个别项目涉及泰国和柬埔寨的多个招聘地点。在开展这项研究的过程中，将提供培训，以加强泰国和柬埔寨调查人员和卫生专业人员开展临床和公共卫生研究的能力。这些项目将通过一项家庭征聘战略联系起来。

DESCRIPTION (provided by applicant): To implement a coordinated program of research into use of antiretroviral (ARV) therapy and the reduction of risk behavior in resource constrained (Thailand) and resource limited (Cambodia) settings. The primary theme of this program is the appropriate and cost-effective use of ARV therapy in developing countries. Specific Aims 1. To assess strategies for inexpensive and logistically simple monitoring of ARV therapy 2. To compare strategies of immediate versus delayed treatment of HIV-infected children in resource limited settings 3. To assess the optimal timing for initiation of ARV therapy in the management of HIV/TB co-infection 4. To investigate behavioral interventions for the reduction of risk behavior and HIV transmission in patients treated with ARV therapy 5. To link the projects using a family unit recruitment strategy 6. To strengthen clinical and prevention research capacity in Thailand and Cambodia 7. To guide clinical and public health policy in Thailand and Cambodia Methods The proposed CIPRA program will investigate treatment and behavioral interventions that will inform public health policy in Thailand, Cambodia and other countries of the region. The research methodologies to be used are randomized clinical trials and observational cohorts. The individual projects involve multiple recruitment sites in Thailand and Cambodia. In the course of conducting this research, training will be provided to strengthen the capacity of Thai and Cambodian investigators and health professionals in the conduct of clinical and public health research. The projects will be linked by a family recruitment strategy.