UNC Developmental Disabilities Research Center

描述(由申请人提供)：北卡罗来纳大学智力低下和发育障碍研究中心(DDRC)是一个跨学科项目，旨在支持和促进与了解神经发育障碍的发病机制和治疗/预防相关的研究。北卡罗来纳大学发改委是北卡罗来纳大学校园内与精神发育迟滞和发育障碍有关的研究和研究培训的中心。该中心目前支持来自21个大学系的63名研究人员，包括135个外部资助的研究项目(102个PHS)，涵盖MRDD研究中心RFA中列出的所有31个内容领域。这一基础广泛的研究计划与一系列关于神经发育障碍的生物行为研究项目很好地结合在一起，NIH资助的几个关于自闭症(ACE Network；STAART中心)、脆性X综合征(NICHD中心计划)和精神分裂症(CONTE中心)的跨学科研究中心的资金就是重点。生物行为研究用于整合与MRDD相关的基础生物学和行为研究中的优秀研究计划。39名中心调查人员积极参与了73个资助项目，研究16种神经发育综合征。在过去八年中，发展与发展研究中心取得了成功，最近在北卡罗来纳大学成立了一个耗资2000万美元的新机构，用于研究、教育和治疗发育障碍，即卡罗莱纳发展障碍研究所。 该应用程序寻求支持一个管理核心和四个研究核心--数据管理和统计分析核心、主题注册核心、行为测量核心和发育神经成像核心。这四个研究核心为这一集成的、多学科的MRDD研究项目提供了尖端、高质量和高成本效益的支持。对该中心的支持对北卡罗来纳大学的发育障碍研究和研究培训产生了重大影响。对这个P30研究中心的持续支持是北卡罗来纳大学新卡罗莱纳研究所计划的重要组成部分。

DESCRIPTION (provided by applicant): The University of North Carolina Mental Retardation and Developmental Disabilities Research Center (DDRC) is an interdisciplinary program with a mission to support and promote research relevant to understanding the pathogenesis and treatment/prevention of neurodevelopmental disorders. The UNC DDRC is the focal point for research and research training relevant to mental retardation and developmental disabilities on the UNC campus. This Center currently supports 63 investigators from 21 University departments, and includes 135 externally-funded research projects (102 PHS) covering all 31 content areas listed in the RFA for MRDD Research Centers. This broad-based research program is well integrated around a portfolio of bio-behavioral research projects on neurodevelopmental disorders highlighted by the funding of several NIH-funded, interdisciplinary research centers on autism (ACE Network; STAART Center), fragile X syndrome (NICHD Centers Program) and schizophrenia (Conte Center). Bio-behavioral studies serve to integrate outstanding research programs in basic biological and behavioral research relevant to MRDD. Thirty-nine Center investigators are actively involved in 73 funded projects studying 16 neurodevelopmental syndromes. The success of this DDRC, over the last eight years, has resulted in the recent establishment of a new $20 million institute at UNC for research, education, and treatment of developmental disabilities, the Carolina Institute for Developmental Disabilities. This application seeks support for an Administrative Core and four research cores - the Data Management and Statistical Analysis Core, the Subject Registry Core, the Behavioral Measurement Core; and the Developmental Neuroimaging Core. These four research cores provide cutting-edge, high-quality, and cost effective support for this integrated, multidisciplinary program of MRDD research. Support for this Center has had a major impact on developmental disabilities research and research training at the University of North Carolina. Continued support of this P30 research center is an essential element of the plans for the new Carolina Institute at UNC.