CSHL CANCER CENTER SUPPORT GRANT

简介（申请人提供）：冷泉港实验室癌症中心是一个致力于了解人类癌症基础生物学的基础研究中心。该中心的主要研究重点是了解控制细胞生长和细胞分裂的分子机制，以及这些过程如何在人类肿瘤细胞中发生改变。这种基于细胞的研究主要集中在细胞分裂周期中的关键生物学过程，如基因表达、DMA复制和染色体分离、RNA加工、细胞形态和细胞信号传导机制。与这些基本细胞过程的研究交织在一起的是对协调细胞生长、细胞周期进程、分化和细胞死亡的调节机制的研究。我们越来越多地将人类癌症的遗传学，包括家族性和散发性，整合到这个基础研究项目中，同时也越来越重视创建和使用人类癌症的动物模型。总之，这些方法开始将癌症遗传学与癌症治疗联系起来。最后，我们已经建立了强大的信息学能力，这将有利于大型数据库的分析，包括那些存储序列信息的数据库和那些与临床数据库联系更紧密的数据库。

DESCRIPTION (provided by applicant): The Cancer Center at Cold Spring Harbor Laboratory (CSHL) is a basic research center devoted to the understanding of fundamental biology of human cancer. A principal focus of the research at the Center is to understand the molecular mechanisms that govern cell growth and cell division and how these processes are altered in human tumor cells. This cellular based research focuses mainly on key biological processes, such as gene expression, DMA replication and chromosome segregation during the cell division cycle, RNA processing, cell morphology and cell signaling mechanisms. Intertwined with the research on these fundamental cellular processes is research on the regulatory machineries that coordinate cell growth, cell cycle progression, differentiation and cell death. Increasingly, we have integrated the genetics of human cancer, both familial and sporadic, into this program of basic research, as well as increasing our emphasis on creating and using animal models of human cancer. Together, these approaches are beginning to link cancer genetics to cancer therapy. Finally, we have established a powerful informatics capability that will benefit the analysis of large databases, including those that store sequence information and those more connected to clinical databases. The Cancer Center is organized into three research Programs (Gene Expression, Cancer Genetics and Cell Biology) and eleven Shared Research Resources. Each of the research programs has a strong basic) cancer research focus, but there is increasing research that focuses on clinically important issues such as cancer genetics and cancer therapy. A notable characteristic of the research at the CSHL Cancer Center is the high degree of interactions between the individual research groups. This includes extensive interactions between research groups within programs and in different programs. The Shared Resources provide specialized, state-of-the art equipment and techniques that are available to all Cancer Center Members. These are continually updated and revised as technologies and needs change. This cohesive yet flexible organization has enabled Center investigators to perform research at the highest level, and scientific progress during the last funding period has been substantial.