Program Leaders

项目负责人

• 批准号: 8340278
• 负责人: BRUCE W. STILLMAN
• 金额: $ 15.45万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-17 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8340278
• 关键词: Animal Model; Area; Biology; Cancer Center; Cancer Center at Cold Spring Harbor Laboratory; Cell Proliferation; Computing Methodologies; DNA biosynthesis; Development; Environment; Epigenetic Process; Faculty; Gene Expression Regulation; Genetic Programming; Genome; Genomics; Grant; Head; Individual; Instruction; Knowledge; Laboratories; Malignant Neoplasms; Molecular Genetics; Normal Cell; Play; RNA; Research; Research Personnel; Resource Sharing; Resources; Role; Signal Pathway; Signal Transduction; System; cancer cell; cancer genetics; innovation; meetings; member; novel therapeutics; programs; response; structural biology; success; tool; tumor

PROJECT SUMMARY (See instructions): Cold Spring Harbor Laboratory has three Cancer Center Programs that focus on various aspects of understanding cancer. The Cancer Genetics Program (GR), headed by Dr. Gregory Hannon, focuses on approaches to understanding tumor development, progression and therapy response, using sophisticated tools for genome analysis, innovative animal models and genomics, and computational methods. The Gene Regulation and Cell Proliferation Program (GR), led by Dr. David Spector, has three main focus areas - DNA replication, epigenetics and RNA biology - with a central aim of understanding the regulation of gene expression and aim of understanding the regulation of gene expression and cell proliferation in both normal and cancer cells using various experimental systems as well as structural biology. Members of the Signal Transduction Program (ST), led by Dr. Nicholas Tonks, define the mechanisms by which critical signaling pathways are perturbed in cancer and influence essential functions of cancer cells. The program leaders play an important role in promoting the success of their program by setting its overall direction, allocating resources within the program, as well as through their active involvement in faculty recruitment. They also integrate Individual scientific needs of members within the program through the improvement and development of scientific shared resources. Each program leader facilitates interactions between program members through both formal and informal meetings with individual investigators or groups of investigators. The progress in all three programs has been outstanding and has profoundly advanced our understanding of cancer. The success results in large part from the interactive environment promoted by the Cancer Center.

项目总结（见说明）： 冷泉港实验室有三个癌症中心项目，专注于了解癌症的各个方面。由Gregory Hannon博士领导的癌症遗传学计划（GR）专注于了解肿瘤发展，进展和治疗反应的方法，使用复杂的基因组分析工具，创新的动物模型和基因组学以及计算方法。基因 调控和细胞增殖计划（GR），由大卫斯佩克特博士领导，有三个主要的重点领域- DNA复制，表观遗传学和RNA生物学-的中心目标是了解基因表达的调控，并利用各种实验系统以及结构生物学来了解正常和癌细胞中基因表达和细胞增殖的调控。由Nicholas Tonks博士领导的信号转导计划（ST）的成员定义了关键信号通路在癌症中受到干扰并影响癌细胞基本功能的机制。项目负责人在促进项目成功方面发挥着重要作用，他们制定了项目的总体方向，在项目中分配资源，并积极参与教师招聘。他们还通过改进和整合计划内成员的个人科学需求， 开发科学共享资源。每个项目负责人通过与单个研究者或研究者小组的正式和非正式会议促进项目成员之间的互动。 这三个项目的进展都非常出色，深刻地推进了我们对癌症的理解。成功的结果在很大程度上来自癌症中心促进的互动环境。