Center for Biomedical Research Excellence in the Molecular Basis of Human Disease

描述（由申请人提供）：本提案建立在前一个资助期内取得的成就之上，并请求COBRE（人类疾病分子基础卓越生物医学研究中心）继续支持。在这项COBRE资助的四年期间，来自9个不同部门的22名初级教师得到了指导，其中8名获得了NIH R01资助，另外4名获得了其他形式的校外资助。参与中心活动的另有11名教师，11名博士后/研究助理和9名研究生。该中心的成员发表了175多篇研究论文，并在科学会议上做了38次报告。COBRE所在的分子和细胞生物化学系在国立卫生研究院公立医学院排名中从第28位上升到第12位，在COBRE任职期间在所有医学院排名中上升到第26位。这是通过增加5148302美元的NIH拨款来实现的，不包括COBRE基金。分子医学中心成立于2007年，这是COBRE第一阶段（2004年8月至2009年7月）取得成就的直接结果。

DESCRIPTION (provided by applicant): This proposal builds upon the accomplishments made during the previous funding period and requests continuing support of COBRE, the Center of Biomedical Research Excellence in the Molecular Basis of Human Disease. During the four year period this COBRE grant has been active, 22 junior faculty from 9 different departments were mentored of which 8 received NIH R01 funding and an additional 4 received Other forms of extramural funding. Participating in the activities of the Center has been an additional 11 faculty, 11 postdoctoral/research associates and 9 graduate students. The members of the Center published more than 175 research papers, and made 38 presentations at scientific meetings. The Department of Molecular and Cellular Biochemistry, in which the COBRE is housed, rose from 28th to 12th in NIH rankings in terms of Public Medical Schools, and 26th in terms of all Medical Schools during the tenure of the COBRE. This was accomplished by an increase in $5,148,302 of NIH grant dollars excluding the COBRE funds. The Center for Molecular Medicine was formed in 2007 as a direct consequence of the accomplishments made during the first phase of the COBRE (Aug 2004- July 2009). In the second phase of this COBRE we propose to establish a nationally and internationally recognized research center that will continue to compete effectively for extramural research funding. To accomplish this we propose i) to expand our critical mass of investigators including the mentoring of an additional 5 promising junior investigators who are studying the molecular basis of human disease. This will include a targeted new recruit to the University. We will enhance the opportunity to translate their research to patients by facilitating interactions with clinical faculty. We will continue with the major focus in cancer, diabetes, and neurological diseases, ii) We will expand and continue to develop our core facilities in Proteomics, Chemistry, Microscopy, Protein characterization, and Mouse Genotyping. iii) We will continue to support pilot research projects. This has been a highly effective way to enhance the research of a rather significant number of junior faculty; iv) facilitate the development of a sustainable center through the submission of program project grants and multi-PI grants. We will provide staff resource and pilot funding to enhance these activities. PUBLIC HEALTH RELEVANCE (provided by applicant): To enhance the competitiveness of junior faculty at the University of Kentucky through the funding of promising junior faculty and providing state-of-the-art research cores.