FLYBASE: A DROSOPHILA GENOMIC AND GENETIC DATABASE

简介（申请人提供）：FlyBase是一个长期的信息学资源，为科学界提供主要生物医学遗传模型黑腹果蝇（Drosophila melanogaster）和其他果蝇属的核心遗传和基因组信息。随着主要全基因组数据集和科学文献中信息的持续爆炸，模型生物数据库在捕获、组织和提取关键信息方面的作用对于使用果蝇作为实验系统的研究人员，对于使用果蝇研究结果来告知他们在其他系统上的研究（包括关注人类的研究人员）以及需要这种全面的，结构良好的数据源。FlyBase将继续对科学文献进行整理，通过专家手工整理对D. melanogaster基因组进行注释，通过自动和选择性手动方法相结合对其他果蝇物种进行注释，并捕获大规模功能基因组数据集。这些不同的数据集将被整合到FlyBase数据库中，并通过每月定期更新的FlyBase网站（http://flybase.org）向公众展示。因此，FlyBase作为一个公共门户网站，可以访问由NHGRI和NIH的其他研究所以及其他美国和国际资助机构支持的各种测序和功能基因组学项目产生的数据，以及部分利用这些主要数据集产生的研究文献。新墨西哥大学（University of New Mexico）的一个小组将在FlyBase少数族裔行动计划中发挥核心作用，加入目前参与此次更新的三个FlyBase站点。相关性：在细胞和发育生物学、神经生物学和行为生物学的背景下，对黑腹果蝇的研究一直处于生物学途径和网络研究的前沿。它也是研究变异、复杂性状、种群生物学、生态学和进化最重要的系统之一。来自果蝇研究的见解对人类健康研究具有直接的重要性，这不仅是因为果蝇与人类的基因集和生物过程之间存在巨大的相似性，使果蝇研究能够为人类生物学和疾病的研究提供信息，还因为黑颊果蝇是研究疾病昆虫载体的最接近的模型。

DESCRIPTION (provided by applicant): FlyBase is a long-term informatics resource that provides the scientific community with core genetic and genomic information on the major biomedical genetic model, Drosophila melanogaster, and other flies of the genus Drosophila. With the continuing explosion of information in major genome-wide datasets as well as the scientific literature, the role of a model organism database in capturing, organizing and distilling the key information is essential to researchers using Drosophila as their experimental system, to groups using the results of Drosophila research to inform their studies on other systems (including researchers focusing on humans), and to computational biologists who require such comprehensive, well structured data sources. FlyBase will continue to curate the scientific literature, annotate the D. melanogaster genome through expert manual curation, annotate the other Drosophila species by a combination of automatic and selective manual approaches, and capture large-scale functional genomics datasets. These diverse sets of data will be integrated within the FlyBase database and presented to the public through regular monthly updates to the FlyBase website (http://flybase.org). FlyBase thus serves as one of the public portals to data produced by a variety of sequencing and functional genomics projects supported by NHGRI and the other institutes of NIH, as well as by other U.S. and international funding agencies, and to the research literature that is produced in part by taking advantage of these major datasets. Joining the three currently participating FlyBase sites for this renewal is a group at the University of New Mexico which will play a central role in the FlyBase Minority Action Plan. RELEVANCE: Research on Drosophila melanogaster continues to be at the forefront of studies of biological pathways and networks in the context of cell and developmental biology, neurobiology and behavioral biology. It has also been one of the most significant systems for studying variation, complex traits, population biology, ecology and evolution. The insights from Drosophila research are of direct importance to human health research, both because of the tremendous similarities between the Drosophila and human gene sets and biological processes, allowing Drosophila research to inform studies of human biology and disease, but also because Drosophila melanogaster is the closest model for research on insect vectors of disease.