Analytical Biochemistry

9.1.1摘要：分析生物化学 导演：斯蒂芬·S. Hecht博士 分析生物化学共享资源的使命是提供高质量的分析服务， 使用现有技术的色谱法、质谱法和相关技术， 癌症中心，及时和低成本。主要有3项服务：质谱;生物标志物 应用，特别是与烟草使用有关的应用;以及仪器维护和服务。这 资源仍然是一个杰出的和广泛使用的设施，以支持研究化学 致癌作用和生物标志物的开发和应用方面，特别是研究人员在 致癌和化学预防，预防和病因学课程。质谱 服务对于癌症中心的许多正在进行的研究来说是绝对关键的。烟草致癌物 生物标志物服务在国际上是众所周知的，并且经常被癌症研究机构以外的研究者使用。 中心仪器维护活动是独一无二的，可以节省时间和宝贵的资源。一个伟大 这种共享资源的资产是其成员的专业知识。斯蒂芬·赫克特，莎伦·墨菲，彼得 Villalta和Steven Carmella在马萨诸塞州的分析生物化学领域拥有近100年的专业知识 光谱分析、结构测定和色谱仪器。巨蟹座成员 中心不断呼吁这些人在分析生物化学相关的项目，方法， 开发和仪器故障排除。这座使用率很高且技术出众的设施 继续为其高生产力的用户提供关键服务。

9.1.1 ABSTRACT: ANALYTICAL BIOCHEMISTRY Director: Stephen S. Hecht, Ph.D. The mission of the Analytical Biochemistry Shared Resource is to provide high quality analytical services, using state of the art chromatographic, mass spectrometric, and related techniques, to members of the Cancer Center, promptly and at low cost. There are 3 major services: mass spectrometry; biomarker applications, particularly with respect to tobacco use; and instrument maintenance and service. This resource continues to be an outstanding and extensively used facility in support of studies on chemical aspects of carcinogenesis and biomarker development and application, particularly by investigators in the Carcinogenesis and Chemoprevention, and Prevention and Etiology programs. The mass spectrometry service is absolutely critical to many ongoing studies in the Cancer Center. The tobacco carcinogen biomarker services are internationally known and are frequently used by investigators outside of the Cancer Center. The instrument maintenance activity is unique and saves time and precious resources. One great asset of this Shared Resource is the expertise of its members. Stephen Hecht, Sharon Murphy, Peter Villalta, and Steven Carmella have nearly 100 years of combined expertise in analytical biochemistry, mass spectrometry, structure determination, and chromatographic instrumentation. Members of the Cancer Center continually call on these individuals for guidance in analytical biochemistry-related projects, methods development, and instrument trouble-shooting. This heavily used and technically outstanding facility continues to provide crucial services to its highly productive users.