Biopsychosocial Relationships underlying Indoor Tanning Experience: Project BRITE

描述（由申请人提供）：作为最常见的人类恶性肿瘤，皮肤癌是一个主要的公共卫生问题。紫外线辐射（UVR），特别是室内晒黑室产生的紫外线，会显著增加患皮肤癌的风险。室内晒黑正变得越来越普遍，尤其在青少年和年轻成年女性中流行。虽然许多室内晒黑者是为了美观，但有一小部分经常晒黑的人可能在心理上和身体上都依赖于晒黑。有证据表明，紫外线照射会在体内产生一些物质（例如，阿片样物质-内啡肽），这些物质可能会增加积极的感觉和晒黑的欲望。拟议项目的主要目的是测试一种新的实验范式的可行性和可接受性，以研究紫外线辐射暴露的情感（情感）和生物决定因素和反应，这些因素可能会激发持续的室内晒黑行为。将招募18-25岁的经常和不经常在室内晒黑的女性，并随机分配接受来自标准商业晒黑摊位的UVR和非UVR（安慰剂）光。参与者将在紫外线辐射暴露前后完成心理访谈、问卷调查和血液样本。据推测，经常和不经常室内晒黑的人在心理/情感和生物标志物（ACTH， β -内啡肽）基线水平以及对紫外线暴露的反应以及遗传多态性（mu-阿片受体，OPMR1）方面存在显著差异。我们的团队已经成功地对年轻人进行了几次皮肤癌预防和成瘾研究；因此，我们非常适合和独特地准备进行拟议的项目。这种创新和转化工作对于理解晒黑欲望背后的心理和生物过程非常重要，特别是对于那些暴露在最大程度的破坏性紫外线下的频繁室内晒黑者。更好地了解这些过程可能有助于开展更有效的预防工作，并有助于指导这一领域的公共政策。

DESCRIPTION (provided by applicant): As the most common human malignancy, skin cancer is a major public health concern. Ultraviolet radiation (UVR), specifically that produced by indoor tanning booths contributes significant risk for skin cancer. Indoor tanning is becoming increasingly prevalent and is particularly popular among adolescent and young adult females. While many indoor tanners tan for appearance reasons, a subgroup of frequent tanners may become psychologically and physically dependent on tanning. There is evidence that UVR exposure produces substances in the body (e.g., the opioid beta-endorphin) that may increase positive feelings and the desire to tan. The primary aim of the proposed project is to test the feasibility and acceptability of a novel experimental paradigm to investigate the affective (emotional) and biological determinants of and responses to UVR exposure that may motivate ongoing indoor tanning behavior. 18-25 year-old female frequent and infrequent indoor tanners will be recruited and randomly assigned to receive UVR and non-UVR (placebo) light from standard commercial tanning booths in a within-subjects cross-over design. Participants will complete a psychological interview, questionnaires, and blood samples before and after UVR exposure. It is hypothesized that there will be significant differences between the frequent and the infrequent indoor tanners in psychological/affective and biomarker (ACTH, beta-endorphin) baseline levels and responses to UVR exposure, as well as genetic polymorphisms (the mu-opioid receptor, OPMR1). Our team has successfully conducted several previous skin cancer prevention and addiction studies with young adults; thus, we are ideally suited and uniquely poised to conduct the proposed project. Such innovative and translational work is important to understanding the psychological and biological processes underlying the desire to tan, particularly among frequent indoor tanners who are exposed to the greatest levels of damaging UVR. Better understanding of these processes may facilitate the development of more effective prevention efforts and help guide public policy in this area. PUBLIC HEALTH RELEVANCE: Ultraviolet radiation exposure, especially when from artificial sources such as indoor tanning booths, contributes greatly to skin cancer, the most common form of human malignancy. The proposed study seeks to better understand the psychological and biological processes related to indoor tanning behavior among those at high risk for skin damage: young adult females. Better understanding of these processes may facilitate the development of more effective prevention efforts and help guide public policy in this area.