Translational Cancer Biology Training Program

描述(由申请者提供)：此申请寻求资助马萨诸塞大学医学院(UMMS)新的癌症生物学培训计划，该计划将支持致力于癌症研究事业的6名博士后和2名博士后实习生。该项目将设在密歇根大学癌症生物学系，但将包括来自多个基础科学和临床部门的教师。教师是根据他们在癌症研究方面的科学成就和资助记录、对翻译癌症研究的欣赏以及他们指导学员的经验而被选为参与这一计划的。这一跨部门计划的一个主要目的是为受训人员(其中大多数将是基础科学家)提供对转译癌症研究的欣赏，以及与临床医生有效互动的能力，这将影响和指导他们的职业生涯。三个关键的发展证实了UMMS对癌症的承诺，并证明了我们对培训计划的要求是合理的。这所医学院于2002年成立了癌症生物学系，并从耶鲁大学聘请了达里奥·阿尔蒂耶里博士担任创始主席。其次，阿尔蒂耶里博士还被任命为华盛顿大学马萨诸塞州癌症中心的主任，负责扩大和增强该中心的影响力。最后，在生物医学研究生院的主持下，成立了一个新的癌症生物学研究生课程，该课程是跨部门的。正如下面将更详细讨论的那样，所有这三项努力都是紧密结合在一起的。癌症生物学系是癌症中心的基石，研究生课程与癌症中心的项目相联系。这些努力的首要主题是转化性癌症研究。更具体地说，他们的中心使命是利用UMMS存在的非凡的基础科学事业来管理人类癌症的临床，反过来，使临床问题能够影响和指导基础科学。从本质上讲，这些都是翻译研究的定义原则。这一方法及其实施所产生的基础设施为培养研究生和博士后研究员提供了良好的环境。事实上，拟议的培训计划是我们癌症使命的关键组成部分，它基于我们的翻译和跨部门癌症研究的理念。

DESCRIPTION (provided by applicant): This application seeks funding of a new training program in Cancer Biology at the University of Massachusetts Medical School (UMMS) that will support six post-doctoral and two pre-doctoral trainees who are committed to careers in cancer research. The program will be based in the Department of Cancer Biology at UMMS but it will include faculty from multiple basic science and clinical departments. Faculty have been selected for participation in this program based on their scientific achievements and track record of funding in cancer research, appreciation for translational cancer research and their experience in mentoring trainees. A major intent of this inter-departmental program is to provide the trainees, most of whom will be basic scientists, with an appreciation for translational cancer research and with the ability to interact effectively with clinicians that will influence and guide their careers. Three key developments substantiate the commitment of UMMS to cancer and justify our request for a training program. The medical school established a Department of Cancer Biology in 2002 and recruited Dr. Dario Altieri from Yale to be its founding Chair. Second, Dr. Altieri was also named Director of the UMass Cancer Center and charged with expanding and enhancing the impact of this center. Lastly, a new graduate program in cancer biology was formed that is inter-departmental under the auspices of the Graduate School of Biomedical Sciences. As will be discussed in more detail below, all three of these endeavors are closely integrated. The Department of Cancer Biology is a cornerstone of the Cancer Center, and the graduate program is linked to the programs of the Cancer Center. The overarching theme of these endeavors is translational cancer research. More specifically, their central mission is to harness the extraordinary basic science enterprise that exists at UMMS to the clinical management of human cancers and, conversely, to enable clinical problems to influence and guide basic science. In essence, these are the defining principles of translational research. This approach and the infrastructure that has resulted from its implementation provide an outstanding environment for the training of graduate students and post-doctoral fellows. Indeed, the proposed training program is a critical component of our cancer mission and it is predicated on our philosophy of translational and inter-departmental cancer research.