Training Program in Diabetes Research

此申请是一个更新的应用程序的培训儿科内分泌研究员在国家的最先进的糖尿病 research.该培训计划旨在为芭芭拉糖尿病研究提供多学科培训 戴维斯中心（BDC）和科罗拉多大学医学院（UCSOM）。该提案的基本原理是：1） 在这个国家，儿科内分泌学家严重短缺，特别是那些受过训练和有经验的糖尿病专家。 研究2）糖尿病是儿科人群中日益严重的医疗保健问题， 从个人和健康经济的角度来看，未来的后果3）糖尿病目前的快速发展 调查要求增加在临床，生物化学， 流行病学和行为研究，以开展相关的高质量基础和临床转化研究， 儿科1型和2型糖尿病，将糖尿病研究的进展带到临床竞技场。芭芭拉·戴维斯 中心在年轻研究人员的研究培训方面有着广泛和可靠的记录。BDC和UCSOM有一个 在1型糖尿病的免疫生物学、遗传学和分子生物学领域工作的研究人员建立了良好的网络 糖尿病，以及2型糖尿病的异常病理生理学。这个经验丰富的导师网络是理想的 适合培养下一代年轻的儿科内分泌学家成为独立的糖尿病研究者。地区 芭芭拉戴维斯中心的研究重点包括胰岛细胞生理学，遗传学，分子生物学，移植 免疫学和自身免疫，1型糖尿病的预测和预防，以及流行病学， 预防和治疗1型和2型糖尿病。这些领域的研究是迫切需要的，并已 被确定为对国家公共卫生重要，以解决美国糖尿病的流行。 由NIH支持的糖尿病和内分泌学研究中心加强，该中心建立完善，NIH支持 儿科和成人临床转化研究中心，以及临床营养研究单位，NIH支持 K30临床科学家课程奖，以及公共卫生计划科学的强大的硕士学位。这 申请得到了儿科，内科，预防医学和儿童医院的支持。 丹佛医院（TCH）在我们培训计划的最初四年中，我们已经展示了我们提供强大的 统计学、流行病学、研究方法、人类研究的伦理学和管理、医学 写作，生物化学，药代动力学和分子生物学通过临床科学计划，以及 人类医学遗传学和分子遗传学，包括基因组学、蛋白质组学和代谢组学， 人类遗传学计划。这个教学计划与BDC强大的指导教师相结合， UCSOM已经并将继续允许我们提供培训的年轻儿科内分泌学家需要发展成为 独立的研究人员，能够竞争独立的研究资金。的成功 毕业生获得NIH和JDRF个人指导奖和学术中心的教师职位，以及我们的 吸引优秀学员的能力，明确承诺学术研究事业表明的实力， BDC在糖尿病研究中培训儿科内分泌学家。UCSOM内的计划将支持 该计划包括免疫耐受网络，自身免疫预防中心和TCH研究基金会。

This application is a renewal application for the training of pediatric endocrinology fellows in state of the art diabetes research. This training program is designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC) and The University of Colorado School of Medicine (UCSOM). The proposal's rationale is: 1) there is a critical shortage of pediatric endocrinologists in the country, particularly those trained and experienced in diabetes research 2) Diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economic point of view into the future 3) Current rapid advances in diabetes investigation calls for an increased pool of highly skilled physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out relevant, high quality basic and clinical translational research in pediatric type 1 and type 2 diabetes to bring advances in diabetes research to the clinical arena. The Barbara Davis Center has an extensive and a proven record in research training of young investigators. The BDC and UCSOM have a well established network of investigators working in the immunobiology, genetics, and molecular biology of type 1 diabetes, as well as the abnormal pathophysiology of type 2 diabetes. This network of experienced mentors is ideally suited to develop the next generation of young pediatric endocrinologists into independent diabetes investigators. Areas of research focus within The Barbara Davis Center include islet cell physiology, genetics, molecular biology, transplant immunology, and the autoimmunity, prediction and prevention of type 1 diabetes, as well as the epidemiology, prevention and treatment of type 1 and type 2 diabetes. These areas of research are urgently needed and have been identified as important to the national public health to address the epidemic of diabetes in the U.S. This application is enhanced by the NIH supported Diabetes and Endocrinology Research Center, well established, NIH supported Pediatric and Adult Clinical Translational Research Centers, and a Clinical Nutrition Research Unit, an NIH supported K30 Clinical Scientist Curriculum Award, as well as a strong Masters of Science in Public Health Program. This application has the support of the Departments of Pediatrics, Medicine, Preventive Medicine and The Children's Hospital of Denver (TCH). In the initial four years of our Training Program we have shown our ability to provide strong didactic coursework in statistics, epidemiology, research methods, ethics and regulation of human research, medical writing, biochemistry, pharmacokinetics and molecular biology through the Program in Clinical Science, as well as human medical genetics and molecular genetics, including genomics, proteomics, and metabolomics through the Program in Human Genetics. This didactic program combined with the strong mentoring faculty at the BDC and UCSOM has and will continue to allow us to provide the training young pediatric endocrinologists require to develop into independent investigators, capable of being competitive for independent research funding. The success of our graduates to secure NIH and JDRF individual mentored awards and faculty positions in academic centers, and our ability to attract excellent trainees with a clear commitment to academic research careers indicates the strength of the BDC in training pediatric endocrinologists in diabetes research. Programs within UCSOM which will be supportive of the program include The Immune Tolerance Network, the Autoimmune Prevention Center and TCH Research Foundation.