HMO Research Network Cardiovascular Research Network

描述（由申请人提供）： 尽管在过去几十年中，心血管疾病（CVD）的诊断和治疗取得了许多进展，但它仍然是美国死亡和残疾的主要原因，也是全球发病率和死亡率上升最快的原因之一。这突出了确定CVD流行病学，CVD治疗的使用和后果以及纵向结果的当代和可靠数据的重要性。HMO研究网络是一个由15个非营利健康计划组成的联盟 它在地理上分布在美国各地，其综合研究部门致力于公共领域的研究，通过其在超过1100万健康计划成员中的工作来促进人口健康。这个以社区为基础的网络提供了一个独特的机会，以填补国家心脏、肺和血液研究所在RFA-HL-07-011“社区护理中的心血管研究网络（CVRN）”中确定的与CVD相关的关键知识空白。" 因此，我们建议的总体目标是： 目标1。在HMO研究网络的14个成员计划中建立一个合作的心血管研究网络（CVRN），以创建一个独特的国家资源，利用该网络的心血管专业知识，多样化的社区研究人群和丰富的电子数据系统。 目标二。利用HMO研究网络CVRN进行三个核心研究项目，证明网络的能力，以提供洞察心血管疾病，风险因素和结果的趋势;识别预后因素;和评估和改善管理和相关的心血管疾病的临床结果。核心研究项目将针对高血压控制、华法林治疗房颤和静脉血栓栓塞的护理质量和结果，以及植入式心律转复器的使用和结果。 目标3。在HMO研究网络CVRN内实施有效的模型结构，以快速响应新出现的心血管研究问题，并促进富有成效的外部合作，最大限度地提高CVRN的价值和生产力。 A部分：总体方案审查

DESCRIPTION (provided by applicant): Despite many advances in the diagnosis and treatment of cardiovascular disease (CVD) over the past several decades, it remains the leading cause of death and disability in the US and is one of the fastest rising causes of morbidity and mortality globally. This highlights the importance of ascertainment of contemporary and robust data on CVD epidemiology, use and consequences of CVD therapies, and longitudinal outcomes. The HMO Research Network is a consortium of 15 not-for-profit health plans geographically distributed throughout the U.S. with integrated research divisions committed to public domain research that advances population health through its work among its >11 million health plan members. This community-based network provides a unique opportunity to fill key knowledge gaps related to CVD identified by the National Heart, Lung and Blood Institute in RFA-HL-07-011, "Cardiovascular Research Network (CVRN) in Community-Based Care." Therefore, the overall aims of our proposal are to: Aim 1. To establish a collaborative Cardiovascular Research Network (CVRN) among 14 member plans of the HMO Research Network to create a unique national resource that leverages the network's cardiovascular expertise, diverse community-based study populations, and rich electronic data systems. Aim 2. To leverage the HMO Research Network CVRN to conduct three core research projects that demonstrate the network's capability to provide insights into trends in cardiovascular disease, risk factors, and outcomes; identification of prognostic factors; and evaluation and improvement of management and associated clinical outcomes of cardiovascular conditions. The core research projects will target hypertension control, quality of care and outcomes of warfarin therapy for atrial fibrillation and venous thromboembolism, and the use and outcomes of implantable cardioverter defibrillators. Aim 3. To implement an effective model structure within the HMO Research Network CVRN to rapidly respond to emerging cardiovascular research questions and to facilitate productive external collaborations that maximize the value and productivity of the CVRN. Section A: Overall Program Review