Neuroimaging Core

神经成像核心的总体目标是为HNRC和相关调查人员提供 独特的、非侵入性的方法：1)体内检测和测量艾滋病毒相关的脑损伤，2) 阐明导致这种损害的病理机制，3)进一步调查 使用功能磁共振成像的功能后果，以及4)确定治疗成功和 失败了。在本供资期间，核心基金(1)支持了21个外部供资的项目，结果 例如，在区分艾滋病毒相关脑白质异常和年龄相关脑白质异常的发现中， HIV感染和甲基苯丙胺的脑结构异常的不同模式 依赖，fMRI证据，代偿激活对HIV神经功能障碍的反应，以及MR 与抗逆转录病毒治疗有关的潜在中枢神经损伤的光谱检测；(2)培训12人 神经影像研究的博士后、研究生和本科生；以及(3)提供 在两个多中心试验中向国家和国际合作者提供咨询和援助。我们的目标是 拟议的续期将完成以下工作：a)购置高分辨率结构 图像和组织代谢物测量评估晚期HIV疾病；b)形态计量学的应用 专门为这一人群设计的测量组织丢失和损伤的技术；c)支持 其他HNRC、国家和国际神经成像调查，并提供咨询和培训；d) 数据和专门知识对开发改进的自动形态测量工具的贡献；和e) 对艾滋病毒研究界进行教育，使他们了解治疗神经艾滋病的有前途的新成像方法 研究。此外，在下一个资助期间，具体的新方法开发研究将是 开始确定个别病例活体核磁共振可见异常的组织学特征 身体解剖，使用新的高分辨率组织学和成像方法来了解 MRI可见异常的意义这一核心将通过以下方式加强HNRC的跨学科目标 与其他HNRC核心密切合作，特别是神经医学、神经行为和 神经生物学。神经成像核心的这些广泛功能确保了最先进的技术 为HNRC相关研究提供神经影像支持，HNRC之间的跨学科紧密结合 调查小组，并酌情与更大的国家和国际神经成像联系 社区。

The overall objective of the Neuroimaging Core is to provide the HNRC and associated investigators unique, non-invasive methods for: 1) in vivo detection and measurement of HIV-related brain damage, 2) elucidation of pathological mechanisms that give rise to this damage, 3) further investigation of the functional consequences using fMRI, and 4) identification of neural correlates of treatment success and failure. In the current funding period, the Core has (1) supported 21 extramurally funded projects, resulting in, for example, findings discriminating HIV-related from age-related white matter abnormalities, convergent and divergent patterns of brain structural abnormalities in HIV infection and methamphetamine dependence, fMRI evidence of compensatory activation in response to neural dysfunction in HIV, and MR spectroscopy detection of potential central neuronal injury related to antiretroviral treatment; (2) trained 12 postdoctoral, graduate, and undergraduate trainees in neuroimaging research; and (3) provided consultation and assistance to national and international collaborators in two multicenter trials. Our aims in the proposed renewal period are to accomplish the following: a) acquisition of high-resolution structural images and tissue metabolite measures to evaluate late-stage HIV disease; b) application of morphometry techniques, designed specifically for this population, to measure tissue loss and damage; c) support of other HNRC, national, and international neuroimaging investigations with consultation and training; d) contribution of data and expertise for the development of improved automated morphometry tools; and e) education of the HIV research community regarding promising new imaging methods for NeuroAIDS research. Additionally, during the next funding period specific new method developmental studies will be initiated to define the histological characteristics of visible abnormalities on in vivo MRI in individual cases that come to autopsy, employing novel high-resolution histological and imaging methods to understand of the meaning of MRI-visible abnormalities This Core will enhance HNRC transdisciplinary aims through close collaboration with other HNRC Cores, particularly the Neuromedical, Neurobehavioral, and Neurobiology. These broad-ranging functions of the Neuroimaging Core ensure state of the art neuroimaging support for HNRC-associated studies, close integration between the interdisciplinary HNRC investigative team, and, as appropriate, linkage to the larger national and international neuroimaging community.