MECHANISTIC STUDY OF CLC CHLORIDE-TRANSPORT PROTEINS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 ClC-氯转运蛋白广泛表达。CLC蛋白在神经、肌肉、心血管和上皮功能中发挥核心作用。由于这些重要的生理作用，许多药物是治疗人类疾病的潜在药物靶点。这些蛋白质的缺陷导致人类的肾脏和骨骼疾病，血压调节紊乱，以及癫痫。马杜克实验室的研究涉及电生理、结构和生化方法的组合。目前的研究利用结构信息来理解CLC抑制的机制。研究将包括抑制剂。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. CLC chloride-transport proteins are expressed ubiquitously. CLC proteins play central roles in neuronal, muscular, cardiovascular, and epithelial function. Because of these vital physiological roles, many are potential drug targets for treating human disease. Defects in these proteins are responsible for human diseases of kidney and bone, for disorders of blood-pressure regulation, and for epilepsy. Research in the Maduke lab involves a combination of electrophysiological, structural, and biochemical methods. The current study utilizes structural information to understand the mechanism of CLC inhibition. Studies will include inhibitors.