MASS SPECTROMETRY SERVICE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 生物医学和生物有机质谱学中心为美国各地的学术客户提供质谱学服务。我们可以通过电子碰撞(EI)电离、化学电离(CI)、电喷雾电离(ESI)、快原子轰击(FAB今年退役)电离和基质辅助激光解吸电离(MALDI)来电离样品。我们拥有基于磁扇区、飞行时间、离子陷阱、Q-TOF、FT-ICR和FT-Orbitrap技术的分析仪。我们根据需要为客户提供标称(LR)、精确质量(HR，5ppm)和更高精度的质量(SHR，&lt；1ppm)光谱。我们还可以结合ESI提供LC/MS和LC/MS/MS服务。此外，我们还拥有使蛋白质光谱中的多电荷离子解卷积所需的计算工具。 这为中心提供了对分子质量从小分子到几万道尔顿的样品进行质量分析的能力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Center for Biomedical and Bioorganic Mass Spectrometry provides mass spectral service for academic customers around the United States. We can ionize samples by electron-impact (EI) ionization, chemical ionization (CI), electrospray ionization (ESI), fast atom bombardment (FAB  retired this year) ionization, and matrix assisted laser desorption ionization (MALDI). We have analyzers based on magnetic sector, time-of-flight, ion trap, Q-TOF, FT-ICR, and FT-orbitrap technologies. We provide both nominal (LR), accurate mass (HR, 5ppm) and higher accurate mass (SHR, <1ppm) spectra to our customers as needed. We can also provide LC/MS and LC/MS/MS services in conjunction with ESI. In addition we have the computational tools needed to deconvolute the multiply charged ions in protein spectra. This provides the center with the capability to mass analyze samples with molecular weights ranging from small molecules all the way up to tens of kilodaltons.