Catalytic Enantioselective Diboration Reactions

描述（由申请人提供）：拟议的研究将继续我们在烯烃二硼化反应开发方面的努力。 这些转化允许廉价的烯烃和二烯底物选择性转化为单一对映体手性化合物。 值得注意的是，这些新工艺产生的反应产物类型很难用其他技术制造。 在本论文中，我们将研究不对称二硼化反应的反应机理，以开发更有效的催化剂。 我们还将介绍新的手性单齿配体结构，应该是有用的二硼化反应和其他过程以及。 最后，我们将探讨这些过程的效用，以解决现存的问题，在不对称合成。 公共卫生相关性：单一对映体手性化合物是现代人类治疗中的重要结构。 伴随着结构类型的手性使它们能够适应生理药物靶点。 拟议的研究旨在开发新的工艺，使这些类型的化合物的经济建设。

DESCRIPTION (provided by applicant): The proposed research will continue our efforts in the development of alkene diboration reactions. These transformations allow the selective conversion of inexpensive alkene and diene substrates into single enantiomer chiral compounds. Notably, the types of reaction products that arise from these new processes are difficult to make with other technologies. In the proposed work, we will study the mechanism of enantioselective diboration reactions so that we can develop more efficient catalysts. We will also introduce new chiral monodentate ligand structures that should be useful for the diboration reaction and other processes as well. Lastly, we will explore the utility of these processes to solve extant problems in asymmetric synthesis. PUBLIC HEALTH RELEVANCE: Single enantiomer chiral compounds are important structures in modern human therapeutics. The handedness: that accompanies types of structures enables them to :fit: into physiological drug targets. The proposed research aims to develop new processes that allow for the economical construction of these types of chemical compounds.