ESTABLISHMENT OF SPECIFIC PATHOGEN FREE RHESUS AND PIGTA: AIDS VACCINE DVMT

描述(由申请人提供)：预计对印度恒河猴进行艾滋病相关研究的需求继续超过供应。考虑到非人类灵长类动物越来越多地用于艾滋病相关的机会性感染研究，以及它们预计将用于专注于新出现的疾病和可用于生物恐怖主义的制剂的研究，这种短缺可能会在未来几年持续下去。虽然来源国是潜在的未开发生产的重要储备，但在国际和国内运输非人类灵长类动物的难度越来越大，这表明依赖进口可能只会带来短期的缓解。此外，具有许多研究模型所需的遗传和微生物特征的水平的非人类灵长类目前无法从来源国的生产资源中获得。国内的育种计划成功地培育出了尖端研究所需的具有良好特征的动物，为目前艾滋病疫苗和发病机制研究所需的印度原生恒河猴短缺提供了最佳的长期解决方案。对国内育种项目的投资也将确保未来的供应。这项应用的综合目标是增加ONPRC艾滋病研究扩展SPF繁育群体的能力，为具有遗传特征的印度血统恒河猴提供不含大量地方性和人畜共患病制剂的能力，以提高资源对尖端机会性制剂和疫苗研究的有用性。实现这一目标的具体目标是：a)保持并继续扩大ONPRC艾滋病研究扩大SPF猕猴繁殖群体，使其达到每年能够生产35只剩余动物用于研究的100只成年繁殖雌性猕猴的目标种群；b)通过确保SPF状态和管理用于生产已知亲缘关系和遗传背景的后代的群体，优化ONPRC艾滋病研究扩大SPF猕猴繁殖群体用于疫苗研究的潜在用途；以及c)改善必要的基础设施，以维持ONPRC艾滋病研究扩大SPF猕猴繁殖群体作为一个封闭和受保护的资源。

DESCRIPTION (provided by applicant): The projected need for Indian rhesus macaques for AIDS-related research continues to exceed availability. Given the increase in nonhuman primate use for AIDS-related opportunistic infection research, and their projected use for research focused on emerging disease and agents exploitable for bioterrorism, this shortage will likely continue for years to come. While source countries are a potentially important reserve of untapped production, the increasing difficulty of transporting nonhuman primates both internationally and domestically suggests relying on imports may provide only short term relief. Further, nonhuman primates with the level of genetic and microbial characterization prerequisite for many research models are currently not available from source country production resources. Domestic breeding programs managed to produce the well characterized animals necessary for cutting-edge research offer the best long-term solution for the current shortage of Indian-origin rhesus macaques for AIDS vaccine and pathogenesis studies. Investment in domestic breeding programs will also insure future availability. The comprehensive objective of this application is to increase the capacity of the ONPRC AIDS Research Expanded SPF Breeding Colony to provide genetically characterized Indian-origin rhesus macaques free of a broad number of enzootic and zoonotic agents to enhance the usefulness of the resource for cutting edge opportunistic agent and vaccine research. The specific aims for accomplishing this objective are to a) maintain and continue to expand the ONPRC AIDS Research Expanded SPF Rhesus Macaque Breeding Colony to a target population of 100adult breeder females capable of producing 35 surplus animals annually for research use, b) optimize the potential usefulness of rhesus macaques produced in the ONPRC AIDS Research Expanded SPF Breeding Colony for vaccine research by ensuring SPF status and managing the colony for the production of offspring of known parentage and genetic background that are MHC-defined, and c) improve infrastructure necessary to maintain the ONPRC AIDS Research Expanded SPF Rhesus Macaque Breeding Colony as a closed and protected resource.